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Pregled bibliografske jedinice broj: 1244204

Heritability of the glycan clock of biological age


Mijakovac, Anika; Frkatović, Azra; Hanić, Maja; Ivok, Jelena; Martinić Kavur, Marina; Pučić- Baković, Maja; Spector, Tim; Zoldoš, Vlatka; Mangino, Massimo; Lauc, Gordan
Heritability of the glycan clock of biological age // Frontiers in cell and developmental biology, 10 (2022), 982609, 8 doi:10.3389/fcell.2022.982609 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1244204 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Heritability of the glycan clock of biological age

Autori
Mijakovac, Anika ; Frkatović, Azra ; Hanić, Maja ; Ivok, Jelena ; Martinić Kavur, Marina ; Pučić- Baković, Maja ; Spector, Tim ; Zoldoš, Vlatka ; Mangino, Massimo ; Lauc, Gordan

Izvornik
Frontiers in cell and developmental biology (2296-634X) 10 (2022); 982609, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
IgG glycosylation ; aging biomarker ; biological age ; glycan clock ; heritability

Sažetak
Immunoglobulin G is posttranslationally modified by the addition of complex N-glycans affecting its function and mediating inflammation at multiple levels. IgG glycome composition changes with age and health in a predictive pattern, presumably due to inflammaging. As a result, a novel biological aging biomarker, glycan clock of age, was developed. Glycan clock of age is the first of biological aging clocks for which multiple studies showed a possibility of clock reversal even with simple lifestyle interventions. However, none of the previous studies determined to which extent the glycan clock can be turned, and how much is fixed by genetic predisposition. To determine the contribution of genetic and environmental factors to phenotypic variation of the glycan clock, we performed heritability analysis on two TwinsUK female cohorts. IgG glycans from monozygotic and dizygotic twin pairs were analyzed by UHPLC and glycan age was calculated using the glycan clock. In order to determine additive genetic, shared, and unique environmental contributions, a classical twin design was applied. Heritability of the glycan clock was calculated for participants of one cross-sectional and one longitudinal cohort with three time points to assess the reliability of measurements. Heritability estimate for the glycan clock was 39% on average, suggesting a moderate contribution of additive genetic factors (A) to glycan clock variation. Remarkably, heritability estimates remained approximately the same in all time points of the longitudinal study, even though IgG glycome composition changed substantially. Most environmental contributions came from shared environmental factors (C), with unique environmental factors (E) having a minor role. Interestingly, heritability estimates nearly doubled, to an average of 71%, when we included age as a covariant. This intervention also inflated the estimates of unique environmental factors contributing to glycan clock variation. A complex interplay between genetic and environmental factors defines alternative IgG glycosylation during aging and, consequently, dictates the glycan clock’s ticking. Apparently, environmental factors (including lifestyle choices) have a strong impact on the biological age measured with the glycan clock, which additionally clarifies why this aging clock is one of the most potent biomarkers of biological aging.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Biotehnologija



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.2.2.03.0006 - Centar kompetencija u molekularnoj dijagnostici (CEKOM) (Knjaz, Damir; Lauc, Gordan; Vugrek, Oliver; Polašek, Ozren, EK - KK.01.2.2.03) ( CroRIS)
EK-KF-KK.01.1.1.01.0010 - Znanstveni centar izvrsnosti za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Polašek, Ozren; Secenji, Aleksandar, EK ) ( CroRIS)
--KK.01.1.1.04.0085 - Genomsko inženjerstvo i genska regulacija u staničnim linijama i modelnim organizacijama tehnologija CRISPR / Cas9 CasMouse (CRISPR/Cas9-CasMouse) (Zoldoš, Vlatka; Gajović, Srećko) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
GENOS d.o.o.

Citiraj ovu publikaciju:

Mijakovac, Anika; Frkatović, Azra; Hanić, Maja; Ivok, Jelena; Martinić Kavur, Marina; Pučić- Baković, Maja; Spector, Tim; Zoldoš, Vlatka; Mangino, Massimo; Lauc, Gordan
Heritability of the glycan clock of biological age // Frontiers in cell and developmental biology, 10 (2022), 982609, 8 doi:10.3389/fcell.2022.982609 (međunarodna recenzija, članak, znanstveni)
Mijakovac, A., Frkatović, A., Hanić, M., Ivok, J., Martinić Kavur, M., Pučić- Baković, M., Spector, T., Zoldoš, V., Mangino, M. & Lauc, G. (2022) Heritability of the glycan clock of biological age. Frontiers in cell and developmental biology, 10, 982609, 8 doi:10.3389/fcell.2022.982609.
@article{article, author = {Mijakovac, Anika and Frkatovi\'{c}, Azra and Hani\'{c}, Maja and Ivok, Jelena and Martini\'{c} Kavur, Marina and Pu\v{c}i\'{c}- Bakovi\'{c}, Maja and Spector, Tim and Zoldo\v{s}, Vlatka and Mangino, Massimo and Lauc, Gordan}, year = {2022}, pages = {8}, DOI = {10.3389/fcell.2022.982609}, chapter = {982609}, keywords = {IgG glycosylation, aging biomarker, biological age, glycan clock, heritability}, journal = {Frontiers in cell and developmental biology}, doi = {10.3389/fcell.2022.982609}, volume = {10}, issn = {2296-634X}, title = {Heritability of the glycan clock of biological age}, keyword = {IgG glycosylation, aging biomarker, biological age, glycan clock, heritability}, chapternumber = {982609} }
@article{article, author = {Mijakovac, Anika and Frkatovi\'{c}, Azra and Hani\'{c}, Maja and Ivok, Jelena and Martini\'{c} Kavur, Marina and Pu\v{c}i\'{c}- Bakovi\'{c}, Maja and Spector, Tim and Zoldo\v{s}, Vlatka and Mangino, Massimo and Lauc, Gordan}, year = {2022}, pages = {8}, DOI = {10.3389/fcell.2022.982609}, chapter = {982609}, keywords = {IgG glycosylation, aging biomarker, biological age, glycan clock, heritability}, journal = {Frontiers in cell and developmental biology}, doi = {10.3389/fcell.2022.982609}, volume = {10}, issn = {2296-634X}, title = {Heritability of the glycan clock of biological age}, keyword = {IgG glycosylation, aging biomarker, biological age, glycan clock, heritability}, chapternumber = {982609} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


Citati:





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