Naslov
Utjecaj NH4+ i Gdm+ kationa na termička svojstva DPPS lipidnih membrana
(Impact of NH4+ and Gdm+ cations on thermal properties of DPPS lipid membranes)

Autori
Pašalić, Lea ; Bakarić, Danijela

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
6. simpozij studenata doktorskih studija PMF-a : knjiga sažetaka = 6th Faculty of Science PhD student symposium : book of abstracts / Schneider, Petra - Zagreb : Prirodoslovno-matematički fakultet Sveučilišta u Zagrebu, 2022, 148-149

ISBN
978-953-6076-93-2

Skup
6. Simpozij studenata doktorskih studija PMF-a = 6th Faculty of Science PhD Student Symposium

Mjesto i datum
Zagreb, Hrvatska, 23.04.2022. - 24.04.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Biomembranes ; phospholipids ; spectroscopy ; calorimetry

Sažetak
Phospholipid molecules present an essential part of biomembranes. Phosphatidylserine (PS) is the major anionic phospholipid present in eukaryotic membranes located on the cytosolic leaflet. One of its primary functions seems to be to impart a negative charge to the inner surface of the membrane lipid bilayer [1] which is required for the binding and activation of various peripheral membrane proteins [2]. Lipid-constitued membranes undergo phase transitions, which in addition to temperature, pressure, and pH also depend on the chemical potentials of ions [3]. In this work we are focused on monitoring thermal properties of lipid membranes constituted from 1, 2-dipalmitoyl- snglycero-3-phosphatidylserine (DPPS) in the presence of guanidinium (Gdm+ ) and ammonium (NH4 + ) cations which is manifested in a change in melting temperature (Tm). Using FT-IR spectroscopy, UV-Vis spectrophotometry, and differential scanning calorimetry (DSC) our goal is to understand how thesecations affects thermal properties of DPPS lipid membranes. All experimental results are supported by the computational study.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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