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Pregled bibliografske jedinice broj: 1243762

Green approach to extract bioactive compounds from orange peel employing hydrophilic and hydrophobic deep eutectic solvents


(Nutrition and Food Science, Faculty of Pharmacy, University of Valencia, Valencia, Spain) Viñas-Ospino, A.; Panić, M.; Bagović, M.; Radošević, K.; Esteve, M.J.; Radojčić Redovniković, I.
Green approach to extract bioactive compounds from orange peel employing hydrophilic and hydrophobic deep eutectic solvents // Sustainable Chemistry and Pharmacy, 31 (2023), 100942, 11 doi:10.1016/j.scp.2022.100942 (međunarodna recenzija, članak, znanstveni)


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Naslov
Green approach to extract bioactive compounds from orange peel employing hydrophilic and hydrophobic deep eutectic solvents
(Green approach to extract bioactive compounds from orange peel employing hydrophilic and hydrophobic deep eutectic solvents)

Autori
Viñas-Ospino, A. ; Panić, M. ; Bagović, M. ; Radošević, K. ; Esteve, M.J. ; Radojčić Redovniković, I.

Kolaboracija
Nutrition and Food Science, Faculty of Pharmacy, University of Valencia, Valencia, Spain

Izvornik
Sustainable Chemistry and Pharmacy (2352-5541) 31 (2023); 100942, 11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Bioactive compounds Deep eutectic solvents Orange peel Stability PAMPA

Sažetak
Consumer interest in natural products with advantageous biological impacts on their health has increased in recent years. Therefore, academic and industrial communities have concentrated their research on developing sustainable techniques for extracting bioactive compounds from natural resources. In the present study, extracts rich in bioactive compounds from orange peel were obtained using novel hydrophilic and hydrophobic deep eutectic solvents (DESs). Bioactive compounds such as carotenoids and polyphenols, their stability, antioxidant capacity, permeabil- ity, and biological activity were determined to consider their inclusion in food formulations. The results demonstrated that the highest total carotenoid values were obtained with hydrophobic DESs using DL-Menthol: camphor (163.5 ± 1.1 mg/100gfw), DL-Menthol: Eucalyptol (168.7 ± 1.7mg/100gfw), and lauric acid: octanoic acid (153.1 ± 7.1 mg/100gfw). Total polyphenols were higher in hydrophilic DESs such as proline: malic acid (282.8 ± 7.3 mg/100gfw). The antioxidant values showed that hydrophobic extracts have higher antioxidant activity than traditional solvents. Carotenoid stability was also improved using DL-Menthol: cam- phor, while lactic acid: glucose and proline: malic acid showed a better capacity to stabilize polyphenols. To simulate carotenoid and polyphenol permeation, the Parallel Artificial Mem- brane Permeability Assay (PAMPA) was used and demonstrated that DESs can enhance the per- meability of these bioactive compounds. Biological tests were also performed, and the antiprolif- erative effect in HeLa cells showed only 26.70% cell viability in DL-Menthol: camphor extracts. Based on the presented results, DESs can be used to extract hydrophilic and hydrophobic com- pounds from orange peels, and the obtained extracts could be included in food formulations, avoiding the solvent elimination process.

Izvorni jezik
Engleski

Znanstvena područja
Biotehnologija, Prehrambena tehnologija



POVEZANOST RADA


Projekti:
IP-2019-04-7712 - Racionalan dizajn prirodnih eutektičkih otapala za pripremu i formulaciju kiralnih lijekova (NADESChiralDrug) (Radojčić Redovniković, Ivana, HRZZ - 2019-04) ( CroRIS)
IP-2014-09-9550 - Zelena otapala za zelene tehnologije (GREEN) (Radojčić Redovniković, Ivana, HRZZ - 2014-09) ( CroRIS)
EK-EFRR-KK.01.1.1.07.0007 - Održivo gospodarenje otpadom od proizvodnje vina (0-vinootpad) (Radojčić Redovniković, Ivana, EK - Europski fond za regionalni razvoj, Konkurentnost i kohezija 2014. – 2020., Jačanje kapaciteta za istraživanje, razvoj i inovacije KK.01.1.1.07.0007) ( CroRIS)

Ustanove:
Prehrambeno-biotehnološki fakultet, Zagreb

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

(Nutrition and Food Science, Faculty of Pharmacy, University of Valencia, Valencia, Spain) Viñas-Ospino, A.; Panić, M.; Bagović, M.; Radošević, K.; Esteve, M.J.; Radojčić Redovniković, I.
Green approach to extract bioactive compounds from orange peel employing hydrophilic and hydrophobic deep eutectic solvents // Sustainable Chemistry and Pharmacy, 31 (2023), 100942, 11 doi:10.1016/j.scp.2022.100942 (međunarodna recenzija, članak, znanstveni)
(Nutrition and Food Science, Faculty of Pharmacy, University of Valencia, Valencia, Spain) (Nutrition and Food Science, Faculty of Pharmacy, University of Valencia, Valencia, Spain) Viñas-Ospino, A., Panić, M., Bagović, M., Radošević, K., Esteve, M. & Radojčić Redovniković, I. (2023) Green approach to extract bioactive compounds from orange peel employing hydrophilic and hydrophobic deep eutectic solvents. Sustainable Chemistry and Pharmacy, 31, 100942, 11 doi:10.1016/j.scp.2022.100942.
@article{article, author = {Vi\~{n}as-Ospino, A. and Pani\'{c}, M. and Bagovi\'{c}, M. and Rado\v{s}evi\'{c}, K. and Esteve, M.J. and Radoj\v{c}i\'{c} Redovnikovi\'{c}, I.}, year = {2023}, pages = {11}, DOI = {10.1016/j.scp.2022.100942}, chapter = {100942}, keywords = {Bioactive compounds Deep eutectic solvents Orange peel Stability PAMPA}, journal = {Sustainable Chemistry and Pharmacy}, doi = {10.1016/j.scp.2022.100942}, volume = {31}, issn = {2352-5541}, title = {Green approach to extract bioactive compounds from orange peel employing hydrophilic and hydrophobic deep eutectic solvents}, keyword = {Bioactive compounds Deep eutectic solvents Orange peel Stability PAMPA}, chapternumber = {100942} }
@article{article, author = {Vi\~{n}as-Ospino, A. and Pani\'{c}, M. and Bagovi\'{c}, M. and Rado\v{s}evi\'{c}, K. and Esteve, M.J. and Radoj\v{c}i\'{c} Redovnikovi\'{c}, I.}, year = {2023}, pages = {11}, DOI = {10.1016/j.scp.2022.100942}, chapter = {100942}, keywords = {Bioactive compounds Deep eutectic solvents Orange peel Stability PAMPA}, journal = {Sustainable Chemistry and Pharmacy}, doi = {10.1016/j.scp.2022.100942}, volume = {31}, issn = {2352-5541}, title = {Green approach to extract bioactive compounds from orange peel employing hydrophilic and hydrophobic deep eutectic solvents}, keyword = {Bioactive compounds Deep eutectic solvents Orange peel Stability PAMPA}, chapternumber = {100942} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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