Naslov
Synthesis and Characterization of Nickel(II) macrozone Complexes Derived from 4-formylbenzoic Acid and 3-formylsalicylic Acid

Autori
Smokrović, Kristina ; Hošnjak, Ema ; Sanemit, Saranyarat ; Čipčić-Paljetak, Hana ; Kazazić, Saša ; Mikulandra, Ivana ; Novak, Predrag

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
Magnetic moments in Central Europe (MMCE 2022) – book of abstracts / Bregović, Nikola ; Namjesnik, Danijel ; Novak, Predrag ; Parlov Vuković, Jelena - Zagreb : Hrvatsko kemijsko društvo, 2022, 106-106

Skup
Magnetic Moments in Central Europe (MMCE 2022)

Mjesto i datum
Primošten, Hrvatska, 01.06.2022. - 04.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
macrozones ; nickel(II) complexation ; antibacterial activity

Sažetak
Macrozones, i.e. thiosemicarbazone azithromycin derivatives, are a novel hybrid class of potential anti-infective macrolide compounds (Figure 1.a). [1] It has been well established that complexation of transition metals by the thiosemicarbazone moiety increases antibacterial activity of such ligand.[1] Therefore, we investigated the effect of nickel(II) complexation of macrozones on their antibacterial activity. Nickel(II) complexes of several thiosemicarbazones with 4-formylbenzoic and 3-formylsalicylic acid were prepared and structurally characterized via NMR spectroscopy and single-crystal X-ray diffraction (Figure 1.b). Nickel complexes were then coupled to the 4’’- aminopropyl azithromycin derivative, and the nickel(II) macrozone complexes were characterized using NMR spectroscopy and MS spectrometry. Prepared compounds were screened against a panel of selected Gram-positive and Gram-negative bacterial strains

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA