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Pregled bibliografske jedinice broj: 1241677

STRUCTURE AND INTERACTIONS OF AZITHROMYCIN- THIOSEMICARBAZONE CONJUGATES AS SEEN BY NMR


Novak, Predrag; Mikulandra, Ivana; Jednačak, Tomislav; Habinovec, Iva; Bertoša, Branimir; Zangger, Klaus; Parlov-Vuković, Jelena
STRUCTURE AND INTERACTIONS OF AZITHROMYCIN- THIOSEMICARBAZONE CONJUGATES AS SEEN BY NMR // EUROMAR Abstract book 2022
Utrecht, Nizozemska, 2022. str. PO258-PO258 (poster, međunarodna recenzija, sažetak, znanstveni)


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Naslov
STRUCTURE AND INTERACTIONS OF AZITHROMYCIN- THIOSEMICARBAZONE CONJUGATES AS SEEN BY NMR

Autori
Novak, Predrag ; Mikulandra, Ivana ; Jednačak, Tomislav ; Habinovec, Iva ; Bertoša, Branimir ; Zangger, Klaus ; Parlov-Vuković, Jelena

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
EUROMAR Abstract book 2022 / - , 2022, PO258-PO258

Skup
EUROMAR 2022

Mjesto i datum
Utrecht, Nizozemska, 10-14.07.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
macrolides, macrozones, STD, WaterLogsy, binding epitopes

Sažetak
Macrolides belong to well-known class of antimicrobial agents widely prescribed to treat upper and lower respiratory tract infections. Azithromycin is a semi-synthetic 15-membered macrolide antibiotic derived from erythromycin possessing broad spectrum of antibacterial potency and favourable pharmacokinetics. However, bacterial resistance to marketed antibiotics is growing rapidly and represents one of the major hazards to human health worldwide. Today, there is a high need for discovery of new antibiotics to combat resistance. Novel conjugates of azithromycin and thiosemicarbazones, the macrozones, represent one such class that exhibits promising activities against resistant pathogens. Solution and solid-state structures of several macrozones have been studied and characterised by one- and two-dimensional NMR spectroscopy. Free and ribosome-bound conformations were further evaluated for selected macrozones with highest bioactivity. Saturation transfer difference (STD), WaterLogsy and transferred nuclear Overhauser effect (trNOE) NMR experiments coupled with molecular modelling studies provided valuable data about binding epitopes and bound conformations. The presented results serve as a good platform for discovery and design of new antiinfectives with improved overall biological effect.

Izvorni jezik
Engleski

Znanstvena područja
Kemija



POVEZANOST RADA


Projekti:
HRZZ-IP-2018-01-8098 - Makrozoni, novi konjugati makrolidnih antibiotika: Dizajn, priprava i interakcije (Makrozoni/Macrozones) (Novak, Predrag, HRZZ - 2018-01) ( CroRIS)

Ustanove:
Prirodoslovno-matematički fakultet, Zagreb


Citiraj ovu publikaciju:

Novak, Predrag; Mikulandra, Ivana; Jednačak, Tomislav; Habinovec, Iva; Bertoša, Branimir; Zangger, Klaus; Parlov-Vuković, Jelena
STRUCTURE AND INTERACTIONS OF AZITHROMYCIN- THIOSEMICARBAZONE CONJUGATES AS SEEN BY NMR // EUROMAR Abstract book 2022
Utrecht, Nizozemska, 2022. str. PO258-PO258 (poster, međunarodna recenzija, sažetak, znanstveni)
Novak, P., Mikulandra, I., Jednačak, T., Habinovec, I., Bertoša, B., Zangger, K. & Parlov-Vuković, J. (2022) STRUCTURE AND INTERACTIONS OF AZITHROMYCIN- THIOSEMICARBAZONE CONJUGATES AS SEEN BY NMR. U: EUROMAR Abstract book 2022.
@article{article, author = {Novak, Predrag and Mikulandra, Ivana and Jedna\v{c}ak, Tomislav and Habinovec, Iva and Berto\v{s}a, Branimir and Zangger, Klaus and Parlov-Vukovi\'{c}, Jelena}, year = {2022}, pages = {PO258-PO258}, keywords = {macrolides, macrozones, STD, WaterLogsy, binding epitopes}, title = {STRUCTURE AND INTERACTIONS OF AZITHROMYCIN- THIOSEMICARBAZONE CONJUGATES AS SEEN BY NMR}, keyword = {macrolides, macrozones, STD, WaterLogsy, binding epitopes}, publisherplace = {Utrecht, Nizozemska} }
@article{article, author = {Novak, Predrag and Mikulandra, Ivana and Jedna\v{c}ak, Tomislav and Habinovec, Iva and Berto\v{s}a, Branimir and Zangger, Klaus and Parlov-Vukovi\'{c}, Jelena}, year = {2022}, pages = {PO258-PO258}, keywords = {macrolides, macrozones, STD, WaterLogsy, binding epitopes}, title = {STRUCTURE AND INTERACTIONS OF AZITHROMYCIN- THIOSEMICARBAZONE CONJUGATES AS SEEN BY NMR}, keyword = {macrolides, macrozones, STD, WaterLogsy, binding epitopes}, publisherplace = {Utrecht, Nizozemska} }




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