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Pregled bibliografske jedinice broj: 1240004

Reporting characteristics of allergic rhinitis trials registered on ClinicalTrials.gov and in publications


Paladin, Ivan; Pranić, Shelly
Reporting characteristics of allergic rhinitis trials registered on ClinicalTrials.gov and in publications // 7th World Conference on Research Integrity
Cape Town: World Conferences on Research Integrity, 2022. WCRI2022-164, 1 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1240004 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Reporting characteristics of allergic rhinitis trials registered on ClinicalTrials.gov and in publications

Autori
Paladin, Ivan ; Pranić, Shelly

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

ISBN
0-000-00000-0

Skup
7th World Conference on Research Integrity

Mjesto i datum
Cape Town, Južnoafrička Republika, 29.05.2022. - 01.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Allergic rhinitis ; Randomized Controlled Trial ; Trial Registration Data Set ; ClinicalTrials.gov ; Completeness ; Informativeness

Sažetak
Objective: Data from randomized controlled trials (RCTs) on Allergic rhinitis (AR) should be complete and consistent throughout multiple sources to ensure accurate evidence-based information so our aim was to determine whether there were discrepancies in the reported data from AR trials. Method: This cross-sectional study retrospectively analyzed completed RCTs on AR for completeness, informativeness and major changes to World Health Organization Trial Registration Data Set items as well as completeness of results data in ClinicalTrials.gov and corresponding publications. Results: Omitted items were present in 79 (97.5%) of the 81 trials at initial registration, 67 (82.7%) at last registration, and in 21 (58.3%) of the 36 publications. All 81 trials between first and last registration and all 36 publications had major changes in registration items. Trials that started during or after first registration had less complete registration and more major changes to registration items, χ2=4.101, P=.04 ; χ2=13.711, P=.008, respectively. Major changes in outcomes as the most important were predominantly, changed methodological details in both primary and secondary outcomes between first and last registration as well as in publications although primary outcome changes in ClinicalTrials.gov and in publications included the addition of new outcomes and changes to existing ones. Uninformative reporting of analyzed items was present in both ClinicalTrials.gov and publications. We found that industry-sponsored compared to non-industry funded trials had a statistically significant shorter duration (χ2=6.496, P=.01), more major changes to registration items (χ2=10.192, P=.04) and higher publication rate (χ2=13.558, P<.001). Completeness of results in ClinicalTrials.gov and publications was poor, mostly due to ommited All-cause mortality. Conclusion: Discrepancies in data elements of AR trials are common in both ClinicalTrials.gov and subsequent publications. To ensure a transparency of data reporting from AR trials, multiple stakeholders should be involved to ensure the accuracy and completeness of AR trial data to notice discrepancies before publication.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti, Integrativna bioetika (prirodne, tehničke, biomedicina i zdravstvo, biotehničke, društvene, humanističke znanosti), Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Ustanove:
KBC Split,
Medicinski fakultet, Split,
Sveučilište u Splitu

Profili:

Avatar Url Shelly Pranić (autor)

Avatar Url Ivan Paladin (autor)


Citiraj ovu publikaciju:

Paladin, Ivan; Pranić, Shelly
Reporting characteristics of allergic rhinitis trials registered on ClinicalTrials.gov and in publications // 7th World Conference on Research Integrity
Cape Town: World Conferences on Research Integrity, 2022. WCRI2022-164, 1 (poster, međunarodna recenzija, sažetak, znanstveni)
Paladin, I. & Pranić, S. (2022) Reporting characteristics of allergic rhinitis trials registered on ClinicalTrials.gov and in publications. U: 7th World Conference on Research Integrity.
@article{article, author = {Paladin, Ivan and Prani\'{c}, Shelly}, year = {2022}, pages = {1}, chapter = {WCRI2022-164}, keywords = {Allergic rhinitis, Randomized Controlled Trial, Trial Registration Data Set, ClinicalTrials.gov, Completeness, Informativeness}, isbn = {0-000-00000-0}, title = {Reporting characteristics of allergic rhinitis trials registered on ClinicalTrials.gov and in publications}, keyword = {Allergic rhinitis, Randomized Controlled Trial, Trial Registration Data Set, ClinicalTrials.gov, Completeness, Informativeness}, publisher = {World Conferences on Research Integrity}, publisherplace = {Cape Town, Ju\v{z}noafri\v{c}ka Republika}, chapternumber = {WCRI2022-164} }
@article{article, author = {Paladin, Ivan and Prani\'{c}, Shelly}, year = {2022}, pages = {1}, chapter = {WCRI2022-164}, keywords = {Allergic rhinitis, Randomized Controlled Trial, Trial Registration Data Set, ClinicalTrials.gov, Completeness, Informativeness}, isbn = {0-000-00000-0}, title = {Reporting characteristics of allergic rhinitis trials registered on ClinicalTrials.gov and in publications}, keyword = {Allergic rhinitis, Randomized Controlled Trial, Trial Registration Data Set, ClinicalTrials.gov, Completeness, Informativeness}, publisher = {World Conferences on Research Integrity}, publisherplace = {Cape Town, Ju\v{z}noafri\v{c}ka Republika}, chapternumber = {WCRI2022-164} }




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