Pregled bibliografske jedinice broj: 1239304
UGT2B7 c.-161C>T polymorphism frequency in Croatian population
UGT2B7 c.-161C>T polymorphism frequency in Croatian population // Arhiv za higijenu rada i toksikologiju, 73 (2022), 4; 303-307 doi:10.2478/aiht-2022-73-3663 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1239304 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
UGT2B7 c.-161C>T polymorphism frequency in Croatian
population
Autori
Božina, Tamara ; Karačić, Ena ; Ganoci, Lana ; Čuković-Čavka, Silvija ; Palić, Jozefina ; Božina, Nada ; Šimičević, Livija
Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 73
(2022), 4;
303-307
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
allelic variants ; genotyping ; glucuronidation ; pharmacogenetics ; uridine diphosphate glucuronosyltransferase-2B7
Sažetak
Uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7), enzyme responsible for the elimination of a number of xenobiotics through glucuronidation, is expressed in the gut, kidneys, intestines, and brain. However, data on the frequency of UGT2B7 polymorphisms in the Croatian population are limited. The aim of this study was to assess the frequency of the UGT2B7 c.-161C>T (rs7668258) polymorphism in the Croatian population and to compare it with reported frequencies in other populations. This polymorphism is in complete linkage disequilibrium with the UGT2B7 c.802C>T (UGT2B7*2, rs7439366) variant, which is important in clinical medicine. The study reports data of 501 participants from University Hospital Centre Zagreb. All data were collected and analysed retrospectively. Genotyping was performed by real- time polymerase chain reaction (PCR) using the TaqMan® Drug Metabolism Genotyping Assay for UGT2B7 c.-161C>T (rs7668258). We found that 120 (23.95 %) participants were carriers of the UGT2B7 c.-161CC genotype and 255 (50.9 %) were heterozygous carriers (UGT2B7 c.-161CT), while 126 (25.15 %) were homozygous carriers of the variant allele (UGT2B7 c.-161TT). The frequency of the variant UGT2B7 c.-161C>T allele in this study was T=0.506. The frequency of the UGT2B7 c.-161C>T allelic variants and genotypes in the Croatian population is similar to other European populations.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-UIP-2020-02-8189 - Uloga farmakogenomike u predviđanju nuspojava kardiovaskularnih lijekova (PGx-CardioDrug) (Božina, Tamara, HRZZ - 2020-02) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb
Profili:
Lana Ganoci
(autor)
Ena Karačić
(autor)
Nada Božina
(autor)
Silvija Čuković-Čavka
(autor)
Tamara Božina
(autor)
Jozefina Palić
(autor)
LIVIJA ŠIMIČEVIĆ
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE