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Pregled bibliografske jedinice broj: 1239304

UGT2B7 c.-161C>T polymorphism frequency in Croatian population


Božina, Tamara; Karačić, Ena; Ganoci, Lana; Čuković-Čavka, Silvija; Palić, Jozefina; Božina, Nada; Šimičević, Livija
UGT2B7 c.-161C>T polymorphism frequency in Croatian population // Arhiv za higijenu rada i toksikologiju, 73 (2022), 4; 303-307 doi:10.2478/aiht-2022-73-3663 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1239304 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
UGT2B7 c.-161C>T polymorphism frequency in Croatian population

Autori
Božina, Tamara ; Karačić, Ena ; Ganoci, Lana ; Čuković-Čavka, Silvija ; Palić, Jozefina ; Božina, Nada ; Šimičević, Livija

Izvornik
Arhiv za higijenu rada i toksikologiju (0004-1254) 73 (2022), 4; 303-307

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
allelic variants ; genotyping ; glucuronidation ; pharmacogenetics ; uridine diphosphate glucuronosyltransferase-2B7

Sažetak
Uridine diphosphate glucuronosyltransferase-2B7 (UGT2B7), enzyme responsible for the elimination of a number of xenobiotics through glucuronidation, is expressed in the gut, kidneys, intestines, and brain. However, data on the frequency of UGT2B7 polymorphisms in the Croatian population are limited. The aim of this study was to assess the frequency of the UGT2B7 c.-161C>T (rs7668258) polymorphism in the Croatian population and to compare it with reported frequencies in other populations. This polymorphism is in complete linkage disequilibrium with the UGT2B7 c.802C>T (UGT2B7*2, rs7439366) variant, which is important in clinical medicine. The study reports data of 501 participants from University Hospital Centre Zagreb. All data were collected and analysed retrospectively. Genotyping was performed by real- time polymerase chain reaction (PCR) using the TaqMan® Drug Metabolism Genotyping Assay for UGT2B7 c.-161C>T (rs7668258). We found that 120 (23.95 %) participants were carriers of the UGT2B7 c.-161CC genotype and 255 (50.9 %) were heterozygous carriers (UGT2B7 c.-161CT), while 126 (25.15 %) were homozygous carriers of the variant allele (UGT2B7 c.-161TT). The frequency of the variant UGT2B7 c.-161C>T allele in this study was T=0.506. The frequency of the UGT2B7 c.-161C>T allelic variants and genotypes in the Croatian population is similar to other European populations.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-UIP-2020-02-8189 - Uloga farmakogenomike u predviđanju nuspojava kardiovaskularnih lijekova (PGx-CardioDrug) (Božina, Tamara, HRZZ - 2020-02) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Zagreb

Poveznice na cjeloviti tekst rada:

doi hrcak.srce.hr

Citiraj ovu publikaciju:

Božina, Tamara; Karačić, Ena; Ganoci, Lana; Čuković-Čavka, Silvija; Palić, Jozefina; Božina, Nada; Šimičević, Livija
UGT2B7 c.-161C>T polymorphism frequency in Croatian population // Arhiv za higijenu rada i toksikologiju, 73 (2022), 4; 303-307 doi:10.2478/aiht-2022-73-3663 (međunarodna recenzija, članak, znanstveni)
Božina, T., Karačić, E., Ganoci, L., Čuković-Čavka, S., Palić, J., Božina, N. & Šimičević, L. (2022) UGT2B7 c.-161C>T polymorphism frequency in Croatian population. Arhiv za higijenu rada i toksikologiju, 73 (4), 303-307 doi:10.2478/aiht-2022-73-3663.
@article{article, author = {Bo\v{z}ina, Tamara and Kara\v{c}i\'{c}, Ena and Ganoci, Lana and \v{C}ukovi\'{c}-\v{C}avka, Silvija and Pali\'{c}, Jozefina and Bo\v{z}ina, Nada and \v{S}imi\v{c}evi\'{c}, Livija}, year = {2022}, pages = {303-307}, DOI = {10.2478/aiht-2022-73-3663}, keywords = {allelic variants, genotyping, glucuronidation, pharmacogenetics, uridine diphosphate glucuronosyltransferase-2B7}, journal = {Arhiv za higijenu rada i toksikologiju}, doi = {10.2478/aiht-2022-73-3663}, volume = {73}, number = {4}, issn = {0004-1254}, title = {UGT2B7 c.-161C>T polymorphism frequency in Croatian population}, keyword = {allelic variants, genotyping, glucuronidation, pharmacogenetics, uridine diphosphate glucuronosyltransferase-2B7} }
@article{article, author = {Bo\v{z}ina, Tamara and Kara\v{c}i\'{c}, Ena and Ganoci, Lana and \v{C}ukovi\'{c}-\v{C}avka, Silvija and Pali\'{c}, Jozefina and Bo\v{z}ina, Nada and \v{S}imi\v{c}evi\'{c}, Livija}, year = {2022}, pages = {303-307}, DOI = {10.2478/aiht-2022-73-3663}, keywords = {allelic variants, genotyping, glucuronidation, pharmacogenetics, uridine diphosphate glucuronosyltransferase-2B7}, journal = {Arhiv za higijenu rada i toksikologiju}, doi = {10.2478/aiht-2022-73-3663}, volume = {73}, number = {4}, issn = {0004-1254}, title = {UGT2B7 c.-161C>T polymorphism frequency in Croatian population}, keyword = {allelic variants, genotyping, glucuronidation, pharmacogenetics, uridine diphosphate glucuronosyltransferase-2B7} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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