Pregled bibliografske jedinice broj: 1239279
Synthesis and structural charcaterization of novel 1,2,3- triazole derivatives of benzo[d]oxazole-2-thiol
Synthesis and structural charcaterization of novel 1,2,3- triazole derivatives of benzo[d]oxazole-2-thiol // 19th Ružička Days “Today Science – Tomorrow Industry” / Babić, Jurislav ; Lauš, Ivana (ur.).
Osijek : Zagreb: Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2022. str. 39-39 (poster, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1239279 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Synthesis and structural charcaterization of novel 1,2,3- triazole derivatives of benzo[d]oxazole-2-thiol
Autori
Ostrički, Robert ; Gazivoda Kraljević, Tatjana
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
19th Ružička Days “Today Science – Tomorrow Industry”
/ Babić, Jurislav ; Lauš, Ivana - Osijek : Zagreb : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2022, 39-39
Skup
19. Ružičkini dani "Danas znanost - sutra industrija"
Mjesto i datum
Vukovar, Hrvatska, 21.09.2022. - 23.09.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
1, 2, 3- triazole, benzo[d]oxazole-2-thiol, click chemistry, structural characterization
Sažetak
Treatment of malignant diseases is among the most demanding challenges in modern medicine. Despite significant progress in diagnosing and treating of malignant diseases in the last few decades, there is still a lot of space for improvement. Modern chemotherapy is mostly not selective and attention is focused on the development of new, potent and selective antitumor agents. Benzoxazoles represent an important class of heterocyclic compounds that exhibit remarkable pharmacological activities such as anticancer, antiviral, antibacterial and antifungal. Furthermore, some benzoxazole derivatives are used as fluorescent bleaching agents and functional materials.[1-2] In order to evaluate their antitumor activity, novel derivatives of benzo[d]oxazole-2-thiol containing 1, 2, 3-triazole ring as a linker were synthesized. Propargylated 2-thiobenzoxazole was prepared by cyclization reaction of 2-aminophenol using carbon disulfide, followed by N-alkylation reaction with propargyl bromide as an alkylating reagent. 1, 2, 3-triazole derivatives of benzo[d]oxazole-2-thiol were prepared by utilizing the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) of 2-propargylated benzoxazoles with corresponding azides. Structures of synthesized 1, 2, 3-triazolyl derivatives of benzo[d]oxazole-2-thiol were confirmed by 1H and 13C NMR spectroscopy and mass spectrometry as well. [1] C. P. Kaushik, M. Chahal, .J. Chem. Sci, 2020, 132, 142 [2] R. Sattar, R. Mukhtar, M. Atif, M. Hasnain, A. Irfan, J. Het. Chem., 2020, 57, 2079-2107
Izvorni jezik
Engleski
Znanstvena područja
Kemija
POVEZANOST RADA
Projekti:
HRZZ-IP-2018-01-4682 - Novi spojevi temeljeni na bioizosterima purina za ispitivanje njihovih antitumorskih i antipatogenih djelovanja (PurBioCaPa) (Raić-Malić, Silvana, HRZZ - 2018-01) ( CroRIS)
Ustanove:
Fakultet kemijskog inženjerstva i tehnologije, Zagreb
