Naslov
Epidemiology of Clostridium difficile infections in Croatia-national study

Autori
Budimir, Ana ; Mareković, Ivana ; Mijač, Maja ; Bošnjak, Zrinka ; Payerl-Pal, Marina ; Sušić, Edita ; Matas, Ivanka ; Novak, Anita ; Harmanus, Celine ; Kuijper, Ed

Kolaboracija
ESCMID

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, neobjavljeni rad, znanstveni

Skup
European Congress of Clinical Microbiology and Infectious Diseases

Mjesto i datum
Madrid, Španjolska, 21.04.2018. - 24.04.2018

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
CDI

Sažetak
Background: Clostridium difficile(C. diff) is an important healthcareassociated pathogen, recognized as a frequent cause of diarrhoea and C. diff infections (CDI). Europe has been affected by outbreaks of CDIassociated with theemergence of PCR ribotype 027 and nowadays, C. difficileis responsiblefor 48% of healthcare- associated gastrointestinal infections in acutecare hospitals across Europe. C. diff is considered to bethe 8th most frequent microorganism in HAIs in EU PPS . Theaim of thestudy was to estimatetheincidence of CDIas well as epidemiological and molecular characteristics of CD isolates in Croatia. Materials/methods: During 6-month period (June- December 2016), Reference Centrefor Hospital Infections of Ministry of Health Republic of Croatia senta questionnaires to all hospitals participating in surveillance of hospital-acquired infections. All participating hospitals were using theECDC C. difficile protocol v. 2.2.Laboratories wereasked to send first 10 isolates or stool samples originated from CDI–positive patients. A total of 26 hospitals participated in thestudy: 6 tertiary, 10 secondary hospitals, 5 specialized hospitals, and 5 primary hospitals. Hospitals sent their feedback reports in December 2016 and January 2017. CD isolates from 7 laboratories weresent to UHC laboratory for CD confirmation and susceptiblity testing. PCR ribotyping was performed in MUMC, Leiden. Results:Total number of recorded HA CDI cases was 587, among which 58 of them wererecurrent ones.Thesum of positive CD tests was 671, out of 5008 tests performed.The number of CDI tests was 24.2 per 10 000 patientbed days and a mean of 2.84 cases of CDI per 10 000 patient -days. GDH screening and NAAT were most commonly used diagnostic methods in our laboratories. The most common ribotypeamong CD isolates was type 176 (36%), followed by 027 (16%), 022, 077 etc. Conclusions:This is thefirst national study on incidence of CDIand molecular characteristics of CD isolates in Croatia. In comparison to somecountries, the number of CDIepisodes per 10 000 hospital-bed days was low, and thereason for such low numbers could beeither good infection control practices or underreporting.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA