Pregled bibliografske jedinice broj: 1238554
ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population
ABCG2 and SLCO1B1 gene polymorphisms in the Croatian population // Annals of human biology, (2022), 1-9; 36382878, 9 doi:10.1080/03014460.2022.2140826 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1238554 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
ABCG2 and SLCO1B1 gene polymorphisms in the Croatian
population
Autori
Božina, Tamara ; Ganoci, Lana ; Karačić, Ena ; Šimičević, Livija ; Vrkić-Kirhmajer, Majda ; Klarica- Domjanović, Iva ; Križ, Tena ; Sertić, Zrinka ; Božina, Nada
Izvornik
Annals of human biology (0301-4460)
(2022), 1-9;
36382878, 9
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
ABCG2 ; Croatian population ; SLCO1B1 ; drug transporters ; gene polymorphism
Sažetak
Background: Organic anion-transporting polypeptide 1B1 (OATP1B1) and the ATP-binding cassette subfamily G member 2, ABCG2, are important transporters involved in the transport of endogenous substrates and xenobiotics, including drugs. Genetic polymorphisms of these transporters have effect on transporter activity. There is significant interethnic variability in the frequency of allele variants. Aim: To determined allele and genotype frequencies of ABCG2 and SLCO1B1 genes in Croatian populations of European descent. Subjects and methods: A total of 905 subjects (482 women) were included. Genotyping for ABCG2 c.421C > A (rs2231142) and for SLCO1B1 c.521T > C (rs4149056), was performed by real-time polymerase chain reaction (PCR) using TaqMan® DME Genotyping Assays. Results: For ABCG2 c.421C > A, the frequency of CC, CA and AA genotypes was 81.4%, 17.8% and 0.8% respectively. The frequency of variant ABCG2 421 A allele was 9.7%. For SLCO1B1 c.521T > C, the frequency of TT, TC and CC genotypes was 61.7%, 34.8% and 3.5% respectively. The frequency of variant SLCO1B1 521 C allele was 20.9%. Conclusion: The frequency of the ABCG2 and SLCO1B1 allelic variants and genotypes in the Croatian population is in accordance with other European populations. Pharmacogenetic analysis can serve to individualise drug therapy and minimise the risk of developing adverse drug reactions
Izvorni jezik
Engleski
POVEZANOST RADA
Projekti:
HRZZ-UIP-2020-02-8189 - Uloga farmakogenomike u predviđanju nuspojava kardiovaskularnih lijekova (PGx-CardioDrug) (Božina, Tamara, HRZZ - 2020-02) ( CroRIS)
Ustanove:
Medicinski fakultet, Zagreb
Profili:
Lana Ganoci
(autor)
Ena Karačić
(autor)
Nada Božina
(autor)
Majda Vrkić Kirhmajer
(autor)
Tamara Božina
(autor)
Iva Klarica Domjanović
(autor)
LIVIJA ŠIMIČEVIĆ
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- Social Science Citation Index (SSCI)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE