Naslov
Evaluation of corticospinal tract integrity with navigated TMS corresponds to MRI and the EDSS classifications in multiple sclerosis
(Evaluation of corticospinal tract integrity with navigated TMS corresponds to MRI and the EDSS classifications in multiple sclerosis)

Autori
Rogić Vidaković, Maja ; Ćurković Katić, Ana ; Pavelin, Sanda ; Bralić, Antonia ; Mikac, Una ; Šoda, Joško ; Jerković, Ana ; Mastelić, Angela ; Dolić, Krešimir ; Markotić, Anita ; Režić Mužinić, Nikolina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
12th International Symposium on nTMS in Neurosurgery and Neuromodulation

Mjesto i datum
Berlin, Njemačka, 16.12.2022. - 17.12.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
multiple sclerosis, transcranial magnetic stimulation, motor evoked potential, magnetic resonance imaging, EDSS

Sažetak
Background: Examining the integrity of the corticospinal tract by navigated TMS could help in understanding the neurophysiological correlates of multiple sclerosis (MS) symptoms. Objective: To investigate MEP measures of corticospinal tract integrity with navigated TMS and its correspondence with neurological (EDSS) and neuro- radiological (MRI) classifications in people with relapsing-remitting MS (pwMS). Methods: In a cross-sectional study, MEP measures of corticospinal excitability (RMT, MEP latency, MEP amplitude), clinical disease-related (EDSS), and MRI lesion data were collected in 23 pwMS receiving teriflunomide and compared to non- clinical samples. Results: PwMS subjects differed from non-clinical samples in MEP latency for upper and lower extremity muscles. PwMS with altered TMS finding (prolonged MEP latency or absent MEP), compared to pwMS with neat TMS finding, had higher EDSS score [Median = 3.5(range 0-4) vs. 0.5(0- 2.5)] and EDSS functional pyramidal score [Median = 3.0(0-3.5) vs. 0.5(0-2)]. RMT intensity for mapping representations for lower extremity muscles was predictive for EDSS functional pyramidal scores. Overall, TMS findings classified pwMS as the same as EDSS in 70-83% of cases and were similar or more successful than MRI, which corresponded to EDSS in 57- 65% of cases. PwMS with altered TMS findings differed from those with neat TMS finding on the total number of lesions in the brain corticospinal and in cervical corticospinal tract. Conclusions: The correspondence of TMS with MRI, and EDSS classifications implies the clinical utility of navigated TMS in assessing corticospinal tract integrity in pwMS.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

Napomena
In the abstract book: Page 46, A-103

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