Naslov
Theranostic agents for tumor cell and virus-targeted photodynamic therapy

Autori
Jurković, Marta ; Božinović, Ksenija ; Nestić, Davor ; Michail, Evipidis ; Ferger, Matthias ; Lambert, Christoph ; Majhen, Dragomira ; Marder, Todd B. ; Piantanida, Ivo

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Journal of Photochemistry and Photobiology B: Biology / - , 2022, 1011-1344

Skup
6th Mini Symposium of Section of Medicinal and Pharmaceutical Chemistry

Mjesto i datum
Zagreb, Hrvatska, 22.11.2022

Vrsta sudjelovanja
Predavanje

Vrsta recenzije
Domaća recenzija

Ključne riječi
borane ; singlet oxygen ; photodynamic therapy ; fluorescence ; theranostic

Sažetak
In the recently published paper, three tetracationic bistriarylboranes with bis(2, 6- dimethylphenyl4-ethynyl)arene linkers showed high binding affinities towards DNA and RNA, reporting the binding simultaneously by Raman(SERS) and fluorescence changes. In here presented study, mentioned dyes (Figure 1) exhibited very promising photo-induced biological activity on human cell lines and adenovirus type 5 (HAdV5), thus acting as theranostic agents for photodynamic therapy (PDT). PDT is non-invasive antitumor therapy which has several advantages over the traditional treatment modalities. All compounds efficiently entered living cells, showing negligible antiproliferative activity. In addition, bis-thiophene- and anthracene analogues bind non-covalently to HAdV5 virus with high affinity. The anthracene-analogue itself causes a moderate antiviral effect, i.e. decreases the ability of the virus to infect human cells. Most intriguingly, irradiation of bis- thiophene- and anthracene- analogues with visible light (400-700 nm) caused a very rapid (within 1 minute) and strong increase in cytotoxicity, as well as an order of magnitude increased antiviral activity. Additionally, both analogues induced the formation of reactive oxygen species (ROS) in human cells. Photochemical studies of the compounds revealed that they produce singlet oxygen upon irradiation, which correlates with the observed light-induced bioactivity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Interdisciplinarne prirodne znanosti

POVEZANOST RADA