Naslov
Stable methylation loci are associated with systolic blood pressure in a Croatian island population

Autori
Sprague, Alexandar C ; Niu, Liang ; Jandarov, Rooman ; Zhang, Xiang ; Zhang, Ge ; Chen, Aimin ; Šarac, Jelena ; Čoklo, Miran ; Missoni, Saša ; Rudan, Pavao ; Langevin, Scott M. ; Deka, Ranjan

Izvornik
Epigenomics (1750-1911) 14 (2022), 20; 0279, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
850K ; blood ; cardiometabolic ; epigenetics ; epigenome-wide ; epigenomics ; EWAS ; pressure ; SBP ; systolic

Sažetak
Background: The objective was to identify stable and dynamic DNA methylation loci associated with cardiometabolic traits among an adult population from the Croatian island of Hvar. Materials & methods: An epigenome-wide association study was conducted using peripheral blood longitudinally collected at two time points 10 years apart via Infinium MethylationEPIC beadarray (n = 112). Stable and dynamic loci were identified using linear mixed models. Associations between cardiometabolic traits and loci were assessed using linear models. Results: 22 CpG loci were significantly associated with systolic blood pressure. Twenty were stable and two were dynamic. Conclusion: Multiple genes may be involved in the determination of systolic blood pressure level via stable epigenetic programming, potentially established earlier in life.

Izvorni jezik
Engleski

Znanstvena područja
Etnologija i antropologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)

POVEZANOST RADA