Naslov
Use of Statins in Dental Implantology and Their Impact on Osseointegration: Animal Studies

Autori
Katanec, Tomislav ; Gabrić, Dragana

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, znanstveni

Knjiga
Dosage Forms

Urednik/ci
Ahmad, Usama

Izdavač
IntechOpen

Grad
London : Delhi

Godina
2022

Raspon stranica
1-18

ISBN
978-1-80355-211-8

Ključne riječi
statins ; osseointegration ; dental implants ; bone and implant contact ; bone metabolism

Sažetak
Statins are one of the most commonly used drugs for the prevention of atherosclerosis and ischemic heart disease. Statins have an antibacterial effect against oral pathogens, especially against Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Studies on animals that we analyzed in this chapter show that statins promote angiogenesis and osteoblast differentiation. Data on the effect of statins on the process of osseointegration are important in clinical practice and should be an integral part of dental education. PubMed, Cochrane Central, and Web of Science database search was performed for animal studies on statin effects on dental osseointegration. Fifteen studies performed on laboratory animals were identified where statins were applied systemically, locally, orally, subcutaneously, or intraosseously. Titan implants of different diameters were placed in tibia and femur of animals. Statins improved osseointegration and enhanced contact of implant surface with the newly formed bone, as well as significantly increased the volume of newly formed bone in lab animals. The purpose of this chapter is to prove the relationship between local use of statins and better osseointegration, as well as a larger amount of newly formed bone around the implant. Knowledge of the effect of frequently prescribed medications on dental procedures and osseointegration is necessary for both students and physicians.

Izvorni jezik
Engleski

Znanstvena područja
Dentalna medicina

POVEZANOST RADA