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Pregled bibliografske jedinice broj: 1234233

Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX

Radmanić, Leona; Korać, Petra; Gorenec, Lana; Šimičić, Petra; Bodulić, Kristian; Vince, Adriana; Lepej Židovec, Snježana
Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX // Medicina, 58 (2022), 12; 1734, 10 doi:10.3390/medicina58121734 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1234233 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX

Autori
Radmanić, Leona ; Korać, Petra ; Gorenec, Lana ; Šimičić, Petra ; Bodulić, Kristian ; Vince, Adriana ; Lepej Židovec, Snježana

Izvornik
Medicina (1010-660X) 58 (2022), 12; 1734, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
hepatitis C infection ; fibrosis ; SMAD-6 ; CAV-1 ; gene expression

Sažetak
Background and Objectives: The aim of this study was to analyze the expression of genes on transcriptomic levels involved in inflammatory immune responses and the development of fibrosis in patients with chronic hepatitis C. Materials and Methods: Expression patterns of 84 selected genes were analyzed with real-time quantitative RT PCR arrays in the peripheral blood of treatment-naive patients with chronic hepatitis C and healthy controls. The panel included pro- and anti- fibrotic genes, genes coding for extracellular matrix (EMC) structural constituents and remodeling enzymes, cell adhesion molecules, inflammatory cytokines, chemokines and growth factors, signal transduction members of the transforming growth factor- beta (TGF-ß) superfamily, transcription factors, and genes involved in epithelial to mesenchymal transition. Results: The expression of SMAD-6 coding for a signal transduction TGF-beta superfamily member as well as MMP-8 coding for an ECM protein were significantly increased in CHC patients compared with controls. Conclusions: Chronic hepatitis C was also characterized by a significant downregulation of a set of genes including CAV-1, CTGF, TIMP-3, MMP-1, ITGA-1, LOX, ITGA-2, PLG and CEBPB encoding various biological response modifiers and transcription factors. Our results suggest that chronic hepatitis C is associated with distinct patterns of gene expression modulation in pathways associated with the regulation of immune responses and development of fibrosis

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Interdisciplinarne prirodne znanosti, Kliničke medicinske znanosti



POVEZANOST RADA

Projekti:
EK-KK.01.1.1.01.0006 - Jačanje kapaciteta CERVIRVAC-a za istraživanja u virusnoj imunologiji i vakcinologiji (Jonjić, Stipan, EK ) ( CroRIS)

Ustanove:
Medicinski fakultet, Zagreb,
Prirodoslovno-matematički fakultet, Zagreb,
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Profili:

Avatar Url Kristian Bodulić (autor)

Avatar Url Leona Radmanic (autor)

Avatar Url Snježana Židovec-Lepej (autor)

Avatar Url Petra Simicic (autor)

Avatar Url Lana Gorenec (autor)

Avatar Url Adriana Vince (autor)

Avatar Url Petra Korać (autor)

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Radmanić, Leona; Korać, Petra; Gorenec, Lana; Šimičić, Petra; Bodulić, Kristian; Vince, Adriana; Lepej Židovec, Snježana
Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX // Medicina, 58 (2022), 12; 1734, 10 doi:10.3390/medicina58121734 (međunarodna recenzija, članak, znanstveni)
Radmanić, L., Korać, P., Gorenec, L., Šimičić, P., Bodulić, K., Vince, A. & Lepej Židovec, S. (2022) Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX. Medicina, 58 (12), 1734, 10 doi:10.3390/medicina58121734.
@article{article, author = {Radmani\'{c}, Leona and Kora\'{c}, Petra and Gorenec, Lana and \v{S}imi\v{c}i\'{c}, Petra and Boduli\'{c}, Kristian and Vince, Adriana and Lepej \v{Z}idovec, Snje\v{z}ana}, year = {2022}, pages = {10}, DOI = {10.3390/medicina58121734}, chapter = {1734}, keywords = {hepatitis C infection, fibrosis, SMAD-6, CAV-1, gene expression}, journal = {Medicina}, doi = {10.3390/medicina58121734}, volume = {58}, number = {12}, issn = {1010-660X}, title = {Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX}, keyword = {hepatitis C infection, fibrosis, SMAD-6, CAV-1, gene expression}, chapternumber = {1734} }
@article{article, author = {Radmani\'{c}, Leona and Kora\'{c}, Petra and Gorenec, Lana and \v{S}imi\v{c}i\'{c}, Petra and Boduli\'{c}, Kristian and Vince, Adriana and Lepej \v{Z}idovec, Snje\v{z}ana}, year = {2022}, pages = {10}, DOI = {10.3390/medicina58121734}, chapter = {1734}, keywords = {hepatitis C infection, fibrosis, SMAD-6, CAV-1, gene expression}, journal = {Medicina}, doi = {10.3390/medicina58121734}, volume = {58}, number = {12}, issn = {1010-660X}, title = {Distinct Expression Patterns of Genes Coding for Biological Response Modifiers Involved in Inflammatory Responses and Development of Fibrosis in Chronic Hepatitis C: Upregulation of SMAD-6 and MMP-8 and Downregulation of CAV-1, CTGF, CEBPB, PLG, TIMP-3, MMP-1, ITGA-1, ITGA-2 and LOX}, keyword = {hepatitis C infection, fibrosis, SMAD-6, CAV-1, gene expression}, chapternumber = {1734} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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