Pregled bibliografske jedinice broj: 1233827
Appropriate Shocks and Mortality in Patients With Versus Without Diabetes With Prophylactic Implantable Cardioverter Defibrillators
Appropriate Shocks and Mortality in Patients With Versus Without Diabetes With Prophylactic Implantable Cardioverter Defibrillators // Diabetes care, 43 (2019), 1; 196-200 doi:10.2337/dc19-1014 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1233827 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Appropriate Shocks and Mortality in Patients With
Versus Without Diabetes With Prophylactic
Implantable Cardioverter Defibrillators
Autori
Junttila, M. Juhani ; Pelli, Ari ; Kenttä, Tuomas V. ; Friede, Tim ; Willems, Rik ; Bergau, Leonard ; Malik, Marek ; Vandenberk, Bert ; Vos, Marc A. ; Schmidt, Georg ; Merkely, Bela ; Lubinski, Andrzej ; Svetlosak, Martin ; Braunschweig, Frieder ; Harden, Markus ; Zabel, Markus ; Huikuri, Heikki V. ; Sticherling, Christian ; Zabel, Markus ; Seegers, Joachim ; Bergau, Leonard ; Hasenfuß, Gerd ; Munoz-Exposito, Pascal ; Tichelbäcker, Tobias ; Kirova, Aleksandra ; Schlögl, Simon ; Sritharan, Rajevaa ; Jörß, Katharina ; Macken, Jessica ; Misdaq, Misbah ; Rudolph, Kornelia ; Zabel, Markus ; Hasenfuß, Gerd ; Friede, Tim ; Bauer, Axel ; Meyer-Zürn, Christine ; Eick, Christian ; rechts der Isar, Klinikum ; Schmidt, Goerg ; Müller, Alexander ; Dommasch, Michael ; Sinnecker, Daniel ; Kääb, Stefan ; Sinner, Moritz F. ; Bauer, Axel ; Dissmann, Rüdiger ; Burmester, Ute ; Behrens, Steffen ; Gregor, Martina ; Stefanow, Stefan ; Rüb, Norman ; Wolpert, Christian ; Bimmel, Dieter ; Lieberz, Christiane ; Seegers, Joachim ; Maier, Lars S. ; Schwinger, Robert H.G. ; Blaschke, Florian ; Pieske, Burkert ; Grönefeld, Gerian ; Klein, Gunnar ; Gardiwal, Ajmal ; Merkely, Bela ; Szeplaki, Gabor ; Perge, Peter ; Szavits Nossan, Janko ; Rotkvić, Luka ; Pavlovic, Nikola ; Manola, Sime ; Vinter, Ozren ; Benko, Ivica ; Brusic, Sandro ; Avdovic, Ervin ; Klasan, Marina ; Bakotic, Zoran ; Anic, Ante ; Jurisic, Zrinka ; Lubinski, Andrzej ; Kowalczyk, Emilia ; Kucejko, Tomasz ; Czechowska, Agnieszka ; Wybor, Katarina ; Cygankiewicz, Iwona ; Ptaszyński, Pawel ; Kasprzak, Jaroslaw ; Qavoq, Dariusz ; Guzik, Przemyslaw ; Krauze, Tomasz ; Sterlinski, Maciej ; Hatala, Robert ; Svetlosak, Martin ; Kaliska, Gabriela ; Martinek, Jozef ; Hastrup Svendsen, Jesper ; Thamsborg, Karen ; Hansen, Jim ; Schloett-Hyldelund, Ida-Maria ; Laage-Petersen, Julie ; Willems, Rik ; Vandenberk, Bert ; van Soest, Sofie ; Flevari, Panayota ; Katsaras, Dimitrios ; Katsimardos, Andreas ; Leftheriotis, Dionyssios ; Papangelopoulou, Konstantinia ; Varlamos, Charalambos ; Traykov, Vassil ; Velchev, Vasil ; Iovev, Svetoslav ; Shalganov, Tchavdar ; Sticherling, Christian ; Conen, David ; Giesebart, Sarah ; Novotny, Tomas ; Kozak, Milan ; Taborsky, Milos ; Galuszka, Jan ; Tuinenburg, Anton E. ; Wijers, Sofieke ; Vos, Marc A. ; Wijers, Sofieke ; Dunnink, Albert ; Sprenkeler, David ; Brugada, Josep ; Arbelo, Elena ; Trucco, Emilce ; Vidorreta, Silvia ; Huikuri, Heikki V. ; Kenttä, Tuomas ; Pelli, Ari ; Huikuri, Pirkko ; Koski, Päivi ; Braunschweig, Frieder ; Karlsson, Helena ; Ersgaard, David ; Platonov, Pyotr ; Grönefeld, Gerian ; Klingenheben, Thomas ; EU-CERT-ICD Investigators
Kolaboracija
EU-CERT-ICD Investigators
Izvornik
Diabetes care (0149-5992) 43
(2019), 1;
196-200
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
ICD sudden death cardiomyopathy
Sažetak
OBJECTIVE Diabetes increases the risk of all-cause mortality and sudden cardiac death (SCD). The exact mechanisms leading to sudden death in diabetes are not well known. We compared the incidence of appropriate shocks and mortality in patients with versus without diabetes with a prophylactic implantable cardioverter defibrillator (ICD) included in the retrospective EU-CERT-ICD registry. RESEARCH DESIGN AND METHODS AND RESULTS A total of 3, 535 patients from 12 European EU- CERT-ICD centers with a mean age of 63.7611.2 years (82% males) at the time of ICD implantation were included in the analysis. A total of 995 patients (28%) had a history of diabetes. All patients had an ICD implanted for primary SCD prevention. End points were appropriate shock and all-cause mortality. Mean follow-up time was 3.2 6 2.3 years. Diabetes was associated with a lower risk of appropriate shocks (adjusted hazard ratio [HR] 0.77 [95% CI 0.62–0.96], P 5 0.02). However, patients with diabetes had significantly higher mortality (adjusted HR 1.30 [95% CI 1.11– 1.53], P 5 0.001). CONCLUSIONS All-cause mortality is higher in patients with diabetes than in patients without diabetes with primary prophylactic ICDs. Subsequently, patients with diabetes have a lower incidence of appropriate ICD shocks, indicating that the excess mortality might not be caused primarily by ventricular tachyarrhythmias. These findings suggest a limitation of the potential of prophylactic ICD therapy to improve survival in patients with diabetes with impaired left ventricular function.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti, Kognitivna znanost (prirodne, tehničke, biomedicina i zdravstvo, društvene i humanističke znanosti), Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE