Naslov
Aktivnost serumske acetil-hidrolaze trombocitnog faktora aktivacije u bolesnika s angiografski utvrđenom cerebrovaskularnom stenozom
(Serum platelet-activating factor acetyl-hydrolase activity in patients with angiographically established cerebrovascular stenosis)

Autori
Flegar-Meštrić, Zlata ; Vrhovski-Hebrang, Danijela ; Juretić, Dubravka ; Perkov, Sonja ; Preden-Kereković, Vladimira ; Hebrang, Andrija ; Vidjak, Vinko ; Odak, Drago ; Grga, Ante ; Kosaka, Tetsuya

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Clinical Chemistry and Laboratory Medicine, IFCC-FESCC-EUROMEDLAB Barcelona 2003 / Gerard Siest, Nancy, France - Berlin : Walter de Gruyter, 2003

Skup
EUROMEDLAB Barcelona 2003: 15th IFCC-FESCC European Congress of Clinical Chemistry and Laboratory Medicine 22nd National Congress of the Spanish Society of Clinical Biochemistry and Molecular Pathology

Mjesto i datum
Barcelona, Španjolska, 01.06.2003. - 05.06.2003

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
biokemijski čimbenici rizika ateroskleroze; ukupni homocistein; ukupni antioksidativni status; visoko osjetljivi C-reaktivni protein; cerebrovascularna stenoza; angiografija
(biochemical risk factors of atherosclerosis; total homocysteine; total antioxidative status; high-sensitivity C-reactive protein; cerebrovascular stenosis; angiography)

Sažetak
Oxidation of LDL cholesterol is considered to be one of the key stages in the early development of the atherosclerosis. The platelet-activating factor acetylhydrolase (PAF-AH) seems to have antiatherogenic role as it catabolises oxidized phospholipids on LDL. The aim of this study was to investigate the relation between serum PAF-AH activity in patients with cerebrovascular atherosclerotic changes of different degrees in accordance to the control no-stenosis group. The study comprised 32 patients mean age of 67 years (range 49-80 years) with different degrees of stenosis, established angiographically. The control no-stenosis group consisted of 35 apparently healthy individuals mean age of 55 years (range 44-76 years), with normal cerebral arteries on ultrasound examination. PAF-AH activity was measured with the new automated spectrophotometric assay (AZWELL Auto PAF-AH, Osaka, Japan) on an Olympus AU-600 automatic analyzer (Olympus Mishima Co., Ltd. Shizuoka, Japan). Serum PAF-AH activities did not differ significantly between patient's group with stenosis and the control no-stenosis group (median values 351 U/L versus 380 U/L, >0, 05). Serum PAF-AH activity correlated in control group and the group of patients with total cholesterol (r=0.57 and r=0.56, p<0.05, respectively)and LDL cholesterol (r=0.64 and r=0.48, p<0.05, respectively). The obtained results suggest that serum PAF-AH activity is not associated with cerebrovascular stenosis of different degrees.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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