Naslov
Changing the Landscape of Hypertension Management With SGLT2i 1

Autori
Bilić Ćurčić, Ines ; Ninčević, Vjera ; Canecki Varžić, Silvija ; Prpić Križevac, Ivana ; Milas Ahić, Jasminka ; Mihaljević, Ivica

Izvornik
Southeastern European medical journal (2459-9484) 6 (1) (2022); 1-11

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
SGLT2i, blood pressure, type 2 diabetes, cardiovascular disease

Sažetak
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a newer class of drugs that have primarily been used in the treatment of type 2 diabetes. However, as new findings from clinical trials have become available, their indication has been expanded to include treatment of heart failure and chronic kidney disease without the presence of diabetes. The pathophysiological mechanisms of extraglycemic effects of SGLT2i are still being unraveled, but one of the most prominent consequences is a decrease in blood pressure, which has implications for hemodynamics and arterial stiffness. Recent findings indicate that this class of drugs has a beneficial effect on lowering nocturnal blood pressure (BP), with special importance in type 2 diabetes (DMT2), since unregulated nocturnal hypertension is associated with an increased incidence of cardiovascular (CV) events. In this minireview, we have summarized current knowledge about the effects of SGLT2i on blood pressure, including office, home, and ambulatory BP, and potential implications for treatment of hypertension in diabetic and non-diabetic individuals, with positive effects on cardiorenal outcomes.

Izvorni jezik
Engleski

POVEZANOST RADA