Naslov
A comparative analysis reveals inter-species phenotypic differences in the adult mammalian subthalamic nucleus

Autori
Medenica, Tila ; Bokulić, Ema ; Sedmak, Goran

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, stručni

Izvornik
8th Croatian neuroscience congress : book of abstracts / - Zagreb, 2021, 57-57

Skup
8th Croatian neuroscience congress

Mjesto i datum
Online, 24.09.2021. - 25.09.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Nije recenziran

Ključne riječi
subthalamic nucleus ; transcription factors ; protein expression

Sažetak
The subthalamic nucleus (STN) is a diencephalic structure which is an important part of the basal ganglia circuitry. As such, it has gained clinical interest as a target for deep brain stimulation treatment of Parkinson’s disease. Although it is a clinically relevant structure, little is known about its basic cytochemistry and phenotypical profile. When looking at the existing data, results from different species are often not overlapping and data from one species cannot be extrapolated to another. Because of this, we decided to do a systematic comparison between three species most commonly involved in STN research (human, mouse and rat) and compare the expression profiles of different transcription factors in the adult STN between the species. Our results show that there are many differences in the expression profiles of transcription factors between the three species, and that the STN is not strictly phenotypically conserved among them. Since transcription factors control many other downstream genes, differences in their expression suggest that there is a whole other spectrum of differences in the downstream genes, which raises a question of what is their functional significance, and why has it diverged in different mammals’ STN. Another concern is the fact that there are many experiments conducted with animal models of STN-related research and caution is needed in translating the results to humans since human and rodent STN might not quite be the same.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

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