Pregled bibliografske jedinice broj: 1233361
Cross-reactive antibodies in tick-borne encephalitis: case report and literature review
Cross-reactive antibodies in tick-borne encephalitis: case report and literature review // Antibodies, 11 (2022), 4; 72, 8 doi:10.3390/antib11040072 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1233361 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Cross-reactive antibodies in tick-borne encephalitis: case report and literature review
Autori
Vilibić-Čavlek, Tatjana ; Ferenc, Thomas ; Vujica Ferenc, Mateja ; Bogdanić, Maja ; Potočnik-Hunjadi, Tanja ; Sabadi, Dario ; Savić, Vladimir ; Barbić, Ljubo ; Stevanović, Vladimir ; Monaco, Federica ; Listeš, Eddy ; Savini, Giovanni
Izvornik
Antibodies (2073-4468) 11
(2022), 4;
72, 8
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
tick-borne encephalitis virus ; West Nile virus ; Usutu virus ; flaviviruses ; cross-reactive antibodies
Sažetak
Flaviviruses are a heterogeneous group of viruses that may induce broad antigenic cross-reactivity. We present a patient who was admitted to the infectious disease department with symptoms suggestive of aseptic meningitis. During the clinical workup, the patient reported a tick bite two weeks before the disease onset. High titers of IgM and IgG antibodies to tick-borne encephalitis virus (TBEV) were found in both serum and cerebrospinal fluid (CSF) samples, indicating acute TBEV infection. West Nile virus (WNV) and Usutu virus (USUV) IgM and/or IgG antibodies were also detected, and a virus neutralization test (VNT) was performed. A high titer of TBEV neutralizing (NT) antibodies (640) was detected, which confirmed acute TBE. However, NT antibodies to WNV and USUV were also detected (titer 80 for both viruses). After TBEV and WNV IgG avidity evaluation, previous flavivirus infection was highly suspected (avidity index 82% and 89%, respectively). Blood, CSF, and urine samples were negative for respective viruses’ RNA. The presented case highlights the challenges in flavivirus serodiagnosis. In the published literature, different degrees of cross-reactivity or cross-neutralization between TBEV and dengue, louping ill, Omsk hemorrhagic fever, Langat, and Powassan virus were also observed. Therefore, the serology results should be interpreted with caution, including the possibility of cross- reactivity. In areas where several flaviviruses co-circulate VNT is recommended for disease confirmation.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-7456 - Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske (CRONEUROARBO) (Vilibić Čavlek, Tatjana, HRZZ - 2016-06) ( CroRIS)
Ustanove:
Hrvatski zavod za javno zdravstvo,
Klinička bolnica "Merkur",
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Opća bolnica Varaždin,
Medicinski fakultet, Osijek
Profili:
Vladimir Stevanović
(autor)
Thomas Ferenc
(autor)
Tatjana Vilibić-Čavlek
(autor)
Dario Sabadi
(autor)
Ljubo Barbić
(autor)
Vladimir Savić
(autor)
Maja Bogdanić
(autor)
Eddy Listeš
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Emerging Sources Citation Index (ESCI)
- Scopus