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Pregled bibliografske jedinice broj: 1233360

Quantification of antiviral cytokines in serum, cerebrospinal fluid and urine of patients with tick-borne encephalitis in Croatia


Židovec-Lepej, Snježana; Vilibić-Čavlek, Tatjana; Ilić, Maja; Gorenec, Lana; Grgić, Ivana; Bogdanić, Maja; Radmanić, Leona; Ferenc, Thomas; Sabadi, Dario; Savić, Vladimir et al.
Quantification of antiviral cytokines in serum, cerebrospinal fluid and urine of patients with tick-borne encephalitis in Croatia // Vaccines, 10 (2022), 11; 1825, 13 doi:10.3390/vaccines10111825 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1233360 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Quantification of antiviral cytokines in serum, cerebrospinal fluid and urine of patients with tick-borne encephalitis in Croatia

Autori
Židovec-Lepej, Snježana ; Vilibić-Čavlek, Tatjana ; Ilić, Maja ; Gorenec, Lana ; Grgić, Ivana ; Bogdanić, Maja ; Radmanić, Leona ; Ferenc, Thomas ; Sabadi, Dario ; Savić, Vladimir ; Hruskar, Željka ; Svitek, Luka ; Stevanović, Vladimir ; Perić, Ljiljana ; Lišnjić, Dubravka ; Lakošeljac, Danijela ; Rončević, Dobrica ; Barbić, Ljubo

Izvornik
Vaccines (2076-393X) 10 (2022), 11; 1825, 13

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
tick-borne encephalitis ; cytokines ; cerebrospinal fluid ; serum ; urine

Sažetak
Background: Tick-borne encephalitis virus (TBEV) is one of the most significant arboviruses affecting the human central nervous system (CNS) in Europe. Data on cytokine response in TBEV infection are limited. Methods: We analyzed the cytokine response in serum, cerebrospinal fluid (CSF) and urine samples of patients with TBE. The control group consisted of patients with ‘febrile headache’ who had normal CSF cytology. The panel included 12 cytokines: TNF-α, IL-6, Th1 (IL-2, IFN-γ), Th2 (IL-4, IL-5, IL-13), Th9 (IL-9), Th17 (IL-17A, IL-17F), Th22 (IL- 22) cytokines and IL- 10. Results: TBE patients were more likely to have increased levels of IL-6 and IFN-γ in CSF compared to controls (85.7% vs. 58.8% and 85.7% vs. 47.1%, respectively). However, concentrations of IL-6 (the most abundant cytokine in the CSF of both groups), IL-10 and IL-9 were lower in TBEV patients compared with controls, but the difference was statistically significant for IL-9 only (p = 0.001). By analyzing the cytokine levels in different clinical samples, all measured cytokines were detected in the serum, with the highest concentrations found for IFN-γ, TNF-α, IL- 10, IL-17F and IL-22. Higher concentrations of cytokines in the CSF compared with serum were observed for IL-5, IL-6 and IL-22. All cytokines except IL-13 were detectable in urine but in a small proportion of patients, except for IL-22, which was detectable in 95.8% of patients. Conclusions: Cytokine composition in different clinical samples of TBE patients reveals a different network of early innate immune response cytokines, Th1, Th2, Th9, Th22, Th17 and anti- inflammatory cytokines.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Projekti:
HRZZ-IP-2016-06-7456 - Prevalencija i molekularna epidemiologija emergentnih i re-emergentnih neuroinvazivnih arbovirusnih infekcija na području Hrvatske (CRONEUROARBO) (Vilibić Čavlek, Tatjana, HRZZ - 2016-06) ( CroRIS)

Ustanove:
Hrvatski zavod za javno zdravstvo,
Klinička bolnica "Merkur",
Hrvatski veterinarski institut, Zagreb,
Veterinarski fakultet, Zagreb,
Medicinski fakultet, Zagreb,
Klinički bolnički centar Osijek,
Klinika za infektivne bolesti "Dr Fran Mihaljević"

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Židovec-Lepej, Snježana; Vilibić-Čavlek, Tatjana; Ilić, Maja; Gorenec, Lana; Grgić, Ivana; Bogdanić, Maja; Radmanić, Leona; Ferenc, Thomas; Sabadi, Dario; Savić, Vladimir et al.
Quantification of antiviral cytokines in serum, cerebrospinal fluid and urine of patients with tick-borne encephalitis in Croatia // Vaccines, 10 (2022), 11; 1825, 13 doi:10.3390/vaccines10111825 (međunarodna recenzija, članak, znanstveni)
Židovec-Lepej, S., Vilibić-Čavlek, T., Ilić, M., Gorenec, L., Grgić, I., Bogdanić, M., Radmanić, L., Ferenc, T., Sabadi, D. & Savić, V. (2022) Quantification of antiviral cytokines in serum, cerebrospinal fluid and urine of patients with tick-borne encephalitis in Croatia. Vaccines, 10 (11), 1825, 13 doi:10.3390/vaccines10111825.
@article{article, author = {\v{Z}idovec-Lepej, Snje\v{z}ana and Vilibi\'{c}-\v{C}avlek, Tatjana and Ili\'{c}, Maja and Gorenec, Lana and Grgi\'{c}, Ivana and Bogdani\'{c}, Maja and Radmani\'{c}, Leona and Ferenc, Thomas and Sabadi, Dario and Savi\'{c}, Vladimir and Hruskar, \v{Z}eljka and Svitek, Luka and Stevanovi\'{c}, Vladimir and Peri\'{c}, Ljiljana and Li\v{s}nji\'{c}, Dubravka and Lako\v{s}eljac, Danijela and Ron\v{c}evi\'{c}, Dobrica and Barbi\'{c}, Ljubo}, year = {2022}, pages = {13}, DOI = {10.3390/vaccines10111825}, chapter = {1825}, keywords = {tick-borne encephalitis, cytokines, cerebrospinal fluid, serum, urine}, journal = {Vaccines}, doi = {10.3390/vaccines10111825}, volume = {10}, number = {11}, issn = {2076-393X}, title = {Quantification of antiviral cytokines in serum, cerebrospinal fluid and urine of patients with tick-borne encephalitis in Croatia}, keyword = {tick-borne encephalitis, cytokines, cerebrospinal fluid, serum, urine}, chapternumber = {1825} }
@article{article, author = {\v{Z}idovec-Lepej, Snje\v{z}ana and Vilibi\'{c}-\v{C}avlek, Tatjana and Ili\'{c}, Maja and Gorenec, Lana and Grgi\'{c}, Ivana and Bogdani\'{c}, Maja and Radmani\'{c}, Leona and Ferenc, Thomas and Sabadi, Dario and Savi\'{c}, Vladimir and Hruskar, \v{Z}eljka and Svitek, Luka and Stevanovi\'{c}, Vladimir and Peri\'{c}, Ljiljana and Li\v{s}nji\'{c}, Dubravka and Lako\v{s}eljac, Danijela and Ron\v{c}evi\'{c}, Dobrica and Barbi\'{c}, Ljubo}, year = {2022}, pages = {13}, DOI = {10.3390/vaccines10111825}, chapter = {1825}, keywords = {tick-borne encephalitis, cytokines, cerebrospinal fluid, serum, urine}, journal = {Vaccines}, doi = {10.3390/vaccines10111825}, volume = {10}, number = {11}, issn = {2076-393X}, title = {Quantification of antiviral cytokines in serum, cerebrospinal fluid and urine of patients with tick-borne encephalitis in Croatia}, keyword = {tick-borne encephalitis, cytokines, cerebrospinal fluid, serum, urine}, chapternumber = {1825} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • Social Science Citation Index (SSCI)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus


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