Naslov
A new solid-state promethazine hydrochloride-selective sensor based on functionalized MWCNT

Autori
Peršić, Mateja ; Samardžić, Mirela ; Dandić, Andrea ; Budetić, Mateja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Solutions in Chemistry, Book of Abstracts / - Zagreb, 2022, 109-109

Skup
International Conference Solutions in Chemistry 2022

Mjesto i datum
Sveti Martin na Muri, Hrvatska, 08.11.2022. - 11.11.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
promethazine hydrochloride ; solid-state sensor ; direct potentiometry

Sažetak
Promethazine hydrochloride (PM) is a phenothiazine derivative widely used as antihistaminic, antiemetic, analgesic and anticholinergic drug. Also, it has anesthetic and sedative effect, and can be used as therapeutic agent for treating various mental disorders. Regardless of its benefits, it has adverse effects, such as endocrinal, cardiac and reproductive alterations. Considering that, its determination in pharmaceutical formulations and biological samples is important. Different analytical methods can be used for PM determination but they commonly have drawbacks such as expensive instrumentation, time consuming and complicated procedures, and use of toxic solvents. Due to their simplicity, ion-selective electrodes (ISEs) could be a good alternative. In order to develop ISEs with better properties, ISE membrane can be modified with multi-walled carbon nanotubes (MWCNT) considering their unique properties.4 The new solid-state PM-selective sensor, with liquid type of membrane, was developed using MWCNT functionalized with a sulfate group and PM ion as a sensor material. The new sensor was characterized using direct potentiometry. Response characteristics, dynamic response, influence of pH and selectivity were determined.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA