Naslov
The Relationship between Nrf2 and HO-1 with the Severity of COVID-19 Disease

Autori
Mihić, Damir ; Loinjak, Domagoj ; Maričić, Lana ; Smolić, Robert ; Šahinović, Ines ; Steiner, Kristina ; Viland, Sven ; Šerić, Vatroslav ; Duvnjak, Mario

Izvornik
Medicina (1648-9144) 58 (2022), 11; 1658, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
NF-E2-related factor 2 (Nrf2) ; heme oxygenase-1 (HO-1) ; COVID-19

Sažetak
Nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) have significant roles in the development of a hyperinflammatory state in infectious diseases. We aimed to investigate the association of the serum concentrations of Nrf2 and HO-1 with the severity of COVID-19 disease. The study included 40 subjects with mild and moderately severe forms of the disease (MEWS scoring system ≤2). Twenty of the subjects had MEWS scores of 3 or 4, which indicate a severe form of the disease, and twenty subjects had a MEWS score of ≥5, which indicates a critical form of the disease. HO-1 and Nrf2 were measured using the commercially available Enzyme-Linked Immunosorbent Assay (ELISA). Subjects with the most severe form of COVID-19 (critically ill) had a lower concentration of Nrf2 that negatively correlated with the markers of hyperinflammatory response (CRP, IL-6, ferritin). This observation was not made for HO-1, and the correlation between Nrf2 and HO-1 values was not established. In the mild/moderate form of COVID-19 disease, Nrf2 was associated with an increased 1, 25 dihydroxy vitamin D concentration. The results of this study show that Nrf2 has a role in the body’s anti- inflammatory response to COVID-19 disease, which makes it a potential therapeutic target.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA