Naslov
First condensation of cortical plate is characterized by the expression of projection neuron markers of the deep layers during early human brain development

Autori
Kopić, Janja ; Junaković, Alisa ; Rašin, Mladen Roko ; Kostović, Ivica ; Krsnik, Željka

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
Neuroscience 2022

Mjesto i datum
San Diego (CA), Sjedinjene Američke Države, 12.11.2022. - 16.11.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Podatak o recenziji nije dostupan

Ključne riječi
early cortical plate, cerebral cortex, projection neurons, human brain development

Sažetak
Transition from embryonal to fetal human cortical development at 8 postconceptional weeks (8 PCW) is an event marked by the initial formation of the cortical plate (CP). At that point, cortical neurons align in radial fashion in order to form first collumns. Eventually, CP becomes more compact and increases in size that leads to primary condensation of the CP. As a precursor of future six-layered cerebral neocortex, early CP contains projection neurons gather in this transient fetal compartment. Importantly, future projection neurons need to reach their cortical destination, i.e. the exact laminar position to mature and obtain their molecular profile. Here we aimed to follow the expression pattern of molecular markers of the future projection neurons (CELF1, TBR1, CTIP2, TLE4) during an initial cortical plate formation at the early fetal developmental stages of the human telencephalic wall. We performed immunofluorescence (IF) stainings to reveil projection neuron markers pattern on prenatal postmortem human brain tissue. Our results showed that at the early period of primary CP condensation, projection neuron markers are already expressed in the CP, suggesting their potential role in neurogenetic processes responsible for correct layering of the future cerebral neocortex.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Temeljne medicinske znanosti

POVEZANOST RADA