Pregled bibliografske jedinice broj: 1231307
Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention
Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention // Journal of cardiovascular development and disease, 9 (2022), 11; 395, 12 doi:10.3390/jcdd9110395 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1231307 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients
with STEMI Following Primary Percutaneous Coronary Intervention
Autori
Kumrić, Marko ; Ulrić, Hrvoje ; Bilalić, Admira ; Režić-Mužinić, Nikolina ; Mastelić, Angela ; Markotić, Anita ; Rušić, Doris ; Borovac, Josip Anđelo ; Duplančić, Darko ; Luetić, Marina ; Čović, Ivan ; Tičinović Kurir, Tina ; Božić, Joško
Izvornik
Journal of cardiovascular development and disease (2308-3425) 9
(2022), 11;
395, 12
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
myocardial infarction ; remodeling ; inflammation ; DNAM‐1 ; reperfusion ; monocyte ; natural killer cell
Sažetak
Although the role of inflammation and adverse cardiac remodeling in myocardial infarction (MI) have been extensively explored, gaps in knowledge on the complex interaction between these processes still exist. Data suggest that DNAX accessory molecule-1 (DNAM-1), an activating receptor implicated in NK cell education, may be involved in cardiac remodeling following coronary artery occlusion. In the present study, we aimed to explore the dynamic of DNAM-1+ monocytes and NK cells in peripheral blood in the early phase following reperfusion in patients with ST-elevation MI (STEMI). The study enrolled 49 patients older than 18 years of age diagnosed with STEMI, referred to primary percutaneous coronary intervention (pPCI). Blood samples were obtained at three distinct points (at admission, 3 h, and 24 h after pPCI) and analyzed using flow cytometry. The number of circulating DNAM-1+ monocytes (CD16++ and CD14++) and CD56dimCD16++NK cells was significantly reduced 3 h after pPCI and subsequently returned to initial levels 24 h after procedure (p = 0.003, p < 0.001, and p = 0.002, respectively). Notably, such dynamic was dependent on age of patients. A positive correlation between high sensitivity troponin I levels and number of CD16++DNAM-1+ monocytes in peripheral blood 3 h after pPCI was observed (r = 0.431, p = 0.003). In conclusion, in the present study we delineated the post-reperfusion dynamic of DNAM-1-expresing leukocytes. Additionally, we demonstrated that the number of CD16++ DNAM-1+ monocytes correlate with the extent of myocardial injury.
Izvorni jezik
Engleski
Znanstvena područja
Kliničke medicinske znanosti
POVEZANOST RADA
Ustanove:
KBC Split,
Medicinski fakultet, Split,
Sveučilište u Splitu Sveučilišni odjel zdravstvenih studija
Profili:
Angela Mastelić
(autor)
Marko Kumrić
(autor)
Darko Duplančić
(autor)
Josip Anđelo Borovac
(autor)
Tina Tičinović Kurir
(autor)
Marina Luetić
(autor)
Doris Rušić
(autor)
Anita Markotić
(autor)
Nikolina Režić Mužinić
(autor)
Joško Božić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Emerging Sources Citation Index (ESCI)
- Scopus