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Pregled bibliografske jedinice broj: 1231307

Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention


Kumrić, Marko; Ulrić, Hrvoje; Bilalić, Admira; Režić-Mužinić, Nikolina; Mastelić, Angela; Markotić, Anita; Rušić, Doris; Borovac, Josip Anđelo; Duplančić, Darko; Luetić, Marina et al.
Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention // Journal of cardiovascular development and disease, 9 (2022), 11; 395, 12 doi:10.3390/jcdd9110395 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1231307 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention

Autori
Kumrić, Marko ; Ulrić, Hrvoje ; Bilalić, Admira ; Režić-Mužinić, Nikolina ; Mastelić, Angela ; Markotić, Anita ; Rušić, Doris ; Borovac, Josip Anđelo ; Duplančić, Darko ; Luetić, Marina ; Čović, Ivan ; Tičinović Kurir, Tina ; Božić, Joško

Izvornik
Journal of cardiovascular development and disease (2308-3425) 9 (2022), 11; 395, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
myocardial infarction ; remodeling ; inflammation ; DNAM‐1 ; reperfusion ; monocyte ; natural killer cell

Sažetak
Although the role of inflammation and adverse cardiac remodeling in myocardial infarction (MI) have been extensively explored, gaps in knowledge on the complex interaction between these processes still exist. Data suggest that DNAX accessory molecule-1 (DNAM-1), an activating receptor implicated in NK cell education, may be involved in cardiac remodeling following coronary artery occlusion. In the present study, we aimed to explore the dynamic of DNAM-1+ monocytes and NK cells in peripheral blood in the early phase following reperfusion in patients with ST-elevation MI (STEMI). The study enrolled 49 patients older than 18 years of age diagnosed with STEMI, referred to primary percutaneous coronary intervention (pPCI). Blood samples were obtained at three distinct points (at admission, 3 h, and 24 h after pPCI) and analyzed using flow cytometry. The number of circulating DNAM-1+ monocytes (CD16++ and CD14++) and CD56dimCD16++NK cells was significantly reduced 3 h after pPCI and subsequently returned to initial levels 24 h after procedure (p = 0.003, p < 0.001, and p = 0.002, respectively). Notably, such dynamic was dependent on age of patients. A positive correlation between high sensitivity troponin I levels and number of CD16++DNAM-1+ monocytes in peripheral blood 3 h after pPCI was observed (r = 0.431, p = 0.003). In conclusion, in the present study we delineated the post-reperfusion dynamic of DNAM-1-expresing leukocytes. Additionally, we demonstrated that the number of CD16++ DNAM-1+ monocytes correlate with the extent of myocardial injury.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti



POVEZANOST RADA


Ustanove:
KBC Split,
Medicinski fakultet, Split,
Sveučilište u Splitu Sveučilišni odjel zdravstvenih studija

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com www.mdpi.com

Citiraj ovu publikaciju:

Kumrić, Marko; Ulrić, Hrvoje; Bilalić, Admira; Režić-Mužinić, Nikolina; Mastelić, Angela; Markotić, Anita; Rušić, Doris; Borovac, Josip Anđelo; Duplančić, Darko; Luetić, Marina et al.
Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention // Journal of cardiovascular development and disease, 9 (2022), 11; 395, 12 doi:10.3390/jcdd9110395 (međunarodna recenzija, članak, znanstveni)
Kumrić, M., Ulrić, H., Bilalić, A., Režić-Mužinić, N., Mastelić, A., Markotić, A., Rušić, D., Borovac, J., Duplančić, D. & Luetić, M. (2022) Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention. Journal of cardiovascular development and disease, 9 (11), 395, 12 doi:10.3390/jcdd9110395.
@article{article, author = {Kumri\'{c}, Marko and Ulri\'{c}, Hrvoje and Bilali\'{c}, Admira and Re\v{z}i\'{c}-Mu\v{z}ini\'{c}, Nikolina and Masteli\'{c}, Angela and Markoti\'{c}, Anita and Ru\v{s}i\'{c}, Doris and Borovac, Josip An\djelo and Duplan\v{c}i\'{c}, Darko and Lueti\'{c}, Marina and \v{C}ovi\'{c}, Ivan and Ti\v{c}inovi\'{c} Kurir, Tina and Bo\v{z}i\'{c}, Jo\v{s}ko}, year = {2022}, pages = {12}, DOI = {10.3390/jcdd9110395}, chapter = {395}, keywords = {myocardial infarction, remodeling, inflammation, DNAM‐1, reperfusion, monocyte, natural killer cell}, journal = {Journal of cardiovascular development and disease}, doi = {10.3390/jcdd9110395}, volume = {9}, number = {11}, issn = {2308-3425}, title = {Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention}, keyword = {myocardial infarction, remodeling, inflammation, DNAM‐1, reperfusion, monocyte, natural killer cell}, chapternumber = {395} }
@article{article, author = {Kumri\'{c}, Marko and Ulri\'{c}, Hrvoje and Bilali\'{c}, Admira and Re\v{z}i\'{c}-Mu\v{z}ini\'{c}, Nikolina and Masteli\'{c}, Angela and Markoti\'{c}, Anita and Ru\v{s}i\'{c}, Doris and Borovac, Josip An\djelo and Duplan\v{c}i\'{c}, Darko and Lueti\'{c}, Marina and \v{C}ovi\'{c}, Ivan and Ti\v{c}inovi\'{c} Kurir, Tina and Bo\v{z}i\'{c}, Jo\v{s}ko}, year = {2022}, pages = {12}, DOI = {10.3390/jcdd9110395}, chapter = {395}, keywords = {myocardial infarction, remodeling, inflammation, DNAM‐1, reperfusion, monocyte, natural killer cell}, journal = {Journal of cardiovascular development and disease}, doi = {10.3390/jcdd9110395}, volume = {9}, number = {11}, issn = {2308-3425}, title = {Dynamic of Circulating DNAM-1+ Monocytes and NK Cells in Patients with STEMI Following Primary Percutaneous Coronary Intervention}, keyword = {myocardial infarction, remodeling, inflammation, DNAM‐1, reperfusion, monocyte, natural killer cell}, chapternumber = {395} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
    • Emerging Sources Citation Index (ESCI)
  • Scopus


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