Naslov
Therapeutic potential of faecal microbiota transplantation in dogs

Autori
Zečević, Iva ; Štritof, Zrinka ; Hađina, Suzana ; Stevanović, Vladimir ; Perharić, Matko ; Benvin, Iva ; Cvetnić, Marija ; Martinković, Krešimir ; Habuš, Josipa

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, ostalo, znanstveni

Izvornik
9th International Congress Veterinary Science and Profession - Book of Abstracts / Brkljača Bottegaro, Nika ; Lukač, Maja ; Zdolec, Nevijo ; Vrbanac, Zoran - Zagreb : Veteriranrski fakultet Sveučilišta u Zagrebu, 2021, 95-95

ISBN
978-953-8006-36-4

Skup
9th International Congress "Veterinary Science and Profession "

Mjesto i datum
Zagreb, Hrvatska, 09.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
inestinal dysbiosis, FMT, parvovirosis

Sažetak
Intestinal dysbiosis is a disruption of microbiota homeostasis caused by an imbalance in the complex ecosystem of intestinal microflora. Restoration of the microbiome has been a promising addition to treatment of various gastrointestinal disorders. Its modulation can be achieved by faecal microbiota transplantation (FMT), from a healthy donor into the gastrointestinal tract of an ill recipient. The aim of this study was to investigate efficacy of FMT on the clinical recovery of puppies with parvovirosis. A total of 20 puppies (2–5 mo) where distributed into 2 equal groups: first group received a standard protocol treatment for parvoviral infections (STD) and the other group received FMT in addition to the standard therapy (STD+FMT). Faeces for the FMT procedure were obtained by spontaneous defecation from healthy donors. They had no history of gastrointestinal disorders or administration of antimicrobials in the last year and underwent detailed clinical and laboratory diagnostic procedures. Donor faeces were divided into 10-g aliquots diluted in ringer lactate solution with the addition of glycerol. Transplants were administered into the proximal rectum every other day until improvement of faecal consistency. In the group that received FMT+STD as a treatment protocol, resolution of diarrhoea was significantly faster (p < 0.01) compared to the STD group (median, 3.00 ; range, 1–7 ; mean, 3.8 ; SD, 1.69 days in the FMT group ; median, 6.00 ; range, 5–15 ; mean, 7.5 ; SD, 3.1 days in the STD group). The average number of FMT applications needed for the improvement of the faecal consistency was 2.4 (range 1–4). The FMT procedure of the puppies in the STD+FMT group was not linked to any clinical abnormalities and therefore is considered safe. In conclusion, faecal microbiota transplantation contributed to faster resolution of diarrhoea in puppies with parvoviral infection. Further large-scale studies of FMT therapeutical potential in treatment of various gastrointestinal disorders are needed.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina

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