Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD

Domitrović Spudić, Sandra; Nikolac Perković, Matea; Uzun, Suzana; Nedić Erjavec, Gordana; Kozumplik, Oliver; Švob Štrac, Dubravka; Mimica, Ninoslav; Pivac, Nela

doi:10.1016/j.psychres.2022.114772

Pregled bibliografske jedinice broj: 1229979

Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD

Domitrović Spudić, Sandra; Nikolac Perković, Matea; Uzun, Suzana; Nedić Erjavec, Gordana; Kozumplik, Oliver; Švob Štrac, Dubravka; Mimica, Ninoslav; Pivac, Nela

Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD // Psychiatry research, 316 (2022), 114772, 10 doi:10.1016/j.psychres.2022.114772 (međunarodna recenzija, članak, znanstveni)

CROSBI ID: 1229979 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Reduced plasma BDNF concentration and cognitive decline in veterans with PTSD

Autori
Domitrović Spudić, Sandra ; Nikolac Perković, Matea ; Uzun, Suzana ; Nedić Erjavec, Gordana ; Kozumplik, Oliver ; Švob Štrac, Dubravka ; Mimica, Ninoslav ; Pivac, Nela

Izvornik
Psychiatry research (0165-1781) 316 (2022); 114772, 10

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Alzheimer's disease ; Brain-derived neurotrophic factor ; Cognition ; Mild cognitive impairment ; Post-traumatic stress disorder ; Veterans

Sažetak
Post-traumatic stress disorder (PTSD) is a trauma and stress related disorder frequently associated with cognitive decline. War veterans with PTSD have a higher risk of developing dementia than healthy subjects. Brain derived neurotrophic factor (BDNF) is an important protein that modulates plasticity, memory consolidation and cognitive processes. Lower circulating BDNF levels were related to memory impairment and cognitive deterioration. The aim of this study was to evaluate cognitive deterioration and plasma BDNF concentration in 120 veterans with combat related PTSD, 120 healthy controls, 47 subjects with mild cognitive impairment (MCI) and 76 patients with Alzheimer's disease (AD), and to assess if plasma BDNF concentration might be used as biomarker of cognitive deterioration. Veterans with PTSD had significantly decreased plasma BDNF concentration and worse cognitive performances (assessed using the Mini Mental State Examination, Clock Drawing test and Montreal Cognitive Assessment scores/categories) than healthy subjects, and similarly reduced plasma BDNF and cognitive decline as MCI subjects. Reduced plasma BDNF was found in cognitively impaired subjects. These results suggest that veterans with PTSD should be closely monitored in order to early detect and predict cognitive worsening and promote interventions that might help restore blood BDNF levels and cognitive functions.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA

Projekti:
HRZZ-IP-2019-04-6100 - Terapijski potencijal neurosteroida i neurotrofina u demenciji (TePoNeDe) (Švob Štrac, Dubravka, HRZZ - 2019-04) ( CroRIS)

Ustanove:
Institut "Ruđer Bošković", Zagreb,
Medicinski fakultet, Zagreb,
Klinika za psihijatriju Vrapče,
Opća bolnica Karlovac

Profili:

Ninoslav Mimica (autor)