Naslov
The effects of prolonged antiseptic use during COVID-19 pandemic on skin parameters

Autori
Modun, Darko ; Bročić, Ivana ; Mićanović, Mislav ; Bukić, Josipa ; Rušić, Doris ; Šešelja Perišin, Ana ; Leskur, Dario

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
10th Croatian Congress of Pharmacology and the 1st Croatian Congress of Clinical Pharmacology with International Participation / Mršić-Pelčić, Jasenka ; Vitezić, Dinko ; Janković, Tamara - , 2022, 154-154

Skup
10. hrvatski kongres farmakologije ; 1. hrvatski kongres kliničke farmakologije s međunarodnim sudjelovanjem = 10th Croatian Congress of Pharmacology ; 1st Croatian Congress of Clinical Pharmacology and Therapeutics with International Participation

Mjesto i datum
Opatija, Hrvatska, 22.09.2022. - 25.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
skin ; prolonged antiseptic use ; COVID-19

Sažetak
Introduction: The global coronavirus disease pandemic has put an enormous burden on healthcare workers who faced the increased workload with limited resources, mental exhaustion, stress and a risk of acquiring an infection. Further, there was an increased need to wear protective equipment and practicing hygiene measures such as more frequent use of antiseptics. These measures can lead to changes in the skin, the development of new or exacerbation of an existing inflammatory skin disease. The aim of the study was to determine the changes in the skin parameters after the prolonged use of antiseptics, with and without emollient cream treatment. Materials and methods: Adult participants who had no active skin disease or damage and gave written informed consent were recruited. Effects of the antiseptic use were determined using the repeated exposure model. Antiseptic was applied daily, for three weeks, to the both volar forearms of the participants under occlusion with Finn chambers. One volar forearm was treated with commercially available emollient cream while the other was left untreated. Skin transepidermal water loss - TEWL, hydration and erythema were followed for five weeks. Results: Antiseptic elevated the TEWL values (F(1, 22)=6.743 ; p=0.0165) signifying skin barrier disruption and lowered the skin hydration values (F(1, 22)=13.97 ; p=0.0011), in comparison to undamaged skin. Emollient treatment significantly improved the skin hydration when applied daily after the antiseptic (F(1, 22) = 24.19 ; p<0.001). Conclusions: Prolonged antiseptic use negatively affected the skin parameters while the emollient cream improved some parameters after the concomitant use with antiseptics.

Izvorni jezik
Engleski

Znanstvena područja
Farmacija

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