Naslov
Stable Gastric pentadecapeptide BPC 157 as useful cytoprotective peptide therapy in the heart disturbances, myocardial infarction, heart failure, pulmonary hypertension, arrhythmias, and thrombosis presentation

Autori
Sikirić, Predrag ; Udovičić, Mario ; Barišić, Ivan ; Balenović, Diana ; Živanović Posilović, Gordana ; Strinić, Dean ; Uzun, Sandra ; Sikirić, Sunčana ; Krezić, Ivan ; Žižek, Helena ; Yago, Heidi ; Gojković, Slaven ; Smoday, Ivan Maria ; Kalogjera, Luka ; Vraneš, Hrvoje ; Šola, Marija ; Štrbe, Sanja ; Koprivanac, Antun ; Premužić Meštrović, Ivica ; Meštrović, Tomislav ; Pavić, Predrag ; Škrtić, Anita ; Boban Blagaić, Alenka ; Lovrić Benčić, Martina ; Seiwerth, Sven

Izvornik
Biomedicines (2227-9059) 10 (2022), 11; 2696, 39

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
stable gastric pentadecapeptide BPC 157 ; peptide therapy ; hearth disturbances ; myocardial infarction ; arrhythmias ; congestive heart failure ; pulmonary hypertension ; thrombosis

Sažetak
In heart disturbances, stable gastric pentadecapeptide BPC 157 especial therapy effects combine the therapy of myocardial infarction, heart failure, pulmonary hypertension arrhythmias, and thrombosis prevention and reversal. The shared therapy effect occurred as part of its even larger cytoprotection (cardioprotection) therapy effect (direct epithelial cell protection ; direct endothelium cell protection) that BPC 157 exerts as a novel cytoprotection mediator, which is native and stable in human gastric juice, as well as easily applicable. Accordingly, there is interaction with many molecular pathways, combining maintained endothelium function and maintained thrombocytes function, which counteracted thrombocytopenia in rats that underwent major vessel occlusion and deep vein thrombosis and counteracted thrombosis in all vascular studies ; the coagulation pathways were not affected. These appeared as having modulatory effects on NO-system (NO-release, NOS- inhibition, NO-over-stimulation all affected), controlling vasomotor tone and the activation of the Src-Caveolin-1- eNOS pathway and modulatory effects on the prostaglandins system (BPC 157 counteracted NSAIDs toxicity, counteracted bleeding, thrombocytopenia, and in particular, leaky gut syndrome). As an essential novelty noted in the vascular studies, there was the activation of the collateral pathways. This might be the upgrading of the minor vessel to take over the function of the disabled major vessel, competing with and counteracting the Virchow triad circumstances devastatingly present, making possible the recruitment of collateral blood vessels, compensating vessel occlusion and reestablishing the blood flow or bypassing the occluded or ruptured vessel. As a part of the counteraction of the severe vessel and multiorgan failure syndrome, counteracted were the brain, lung, liver, kidney, gastrointestinal lesions, and in particular, the counteraction of the heart arrhythmias and infarction.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Kliničke medicinske znanosti

POVEZANOST RADA