Naslov
Brentuximab induced splinter nail haemorrhages in a patient with Sézary syndrome: a case report

Autori
Filipović, Nika ; Likić, Robert ; Bulat, Vedrana ; Gašparov, Slavko ; Delaš Aždajić, Marija

Izvornik
British journal of clinical pharmacology (0306-5251) 88 (2022), 8; 3883-3886

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, prikaz, stručni

Ključne riječi
brentuximab ; onychomadesis ; Sézary syndrome ; splinter haemorrhages

Sažetak
Sézary syndrome is a systemic variant of cutaneous T-cell lymphoma characterized by erythroderma, lymphadenopathy and circulating atypical lymphocytes (Sézary cells). It may present with nonspecific lesions on multiple digits. We describe an atyp- ical case of brentuximab-induced splinter nail haemorrhages in a patient with Sézary syndrome, associated with a poor prognosis during follow-up. Concomitantly with the appearance of nail lesions, significant lymphocytosis was detected as well as infil- tration of bone marrow and nail matrices. The lesions followed a precise sequence, which can be traced back to the monthly application of brentuximab and its direct cytotoxic effect on CD30+ T lymphocytes in the nail matrix. Brentuximab- induced nail lesions might be associated with decreased efficacy of brentuximab in this patient with advanced cutaneous T-cell lymphoma.

Izvorni jezik
Engleski

Znanstvena područja
Kliničke medicinske znanosti

POVEZANOST RADA