Naslov
Changes in the liver of BALB/c mice challanged intragastrically with Listeria monocytogenes

Autori
Bubonja, Marina ; Wraber, Branka ; Brumini, Gordana ; Dorić, Miljenko ; Abram, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Publication of the Turkish Microbiological Society No. 44: Abstracts of Invited and Free Papers / Tumbay, Emel - Izmir : META Press, 2002

Skup
FEMS Symposium: The Versatility of Listeria Species

Mjesto i datum
İzmir, Turska, 10.10.2002. - 11.10.2002

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Listeria; intragastric; mouse; liver

Sažetak
We studied the course of Listeria monocytogenes infection in BALB/c mice challanged intragastrically (i.g.), in an attempt to mimic natural listeriosis. The systemic infection was confirmed by positive blood cultures and a high titer of bacteria in the livers of all infected mice. However, repeated lower doses increased the severity of liver infection, resulting in a pronounced necrotizing hepatitis and extreme metabolic liver disfunction according to high levels of serum aminotransferases. During the inflammatory event, chemokine concentrations typically increased more at the local site compared to systemic level. The liver to serum ratio was most pronounced in the case of MIP-1alpha, suggesting its role in the necroinflammatory response in the liver.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA