Pregled bibliografske jedinice broj: 1227082
Search for the molecules underlying neuroregeneration in opossum (Monodelphis domestica)
Search for the molecules underlying neuroregeneration in opossum (Monodelphis domestica) // Proceedings of Genetika 2022 : 9th Congress of the Genetic Society of Slovenia and 9th meeting of the Slovenian Society for Human Genetics with international participation / Zorc, Minja ; Dovč, Peter (ur.).
Ljubljana: Genetic Society of Slovenia, 2022. str. 45-45 (pozvano predavanje, međunarodna recenzija, sažetak, znanstveni)
CROSBI ID: 1227082 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Search for the molecules underlying
neuroregeneration in opossum (Monodelphis domestica)
Autori
Mladinić, Miranda ; Petrović, Antonela ; Tomljanović, Ivana ; Ban, Jelena
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
Proceedings of Genetika 2022 : 9th Congress of the Genetic Society of Slovenia and 9th meeting of the Slovenian Society for Human Genetics with international participation
/ Zorc, Minja ; Dovč, Peter - Ljubljana : Genetic Society of Slovenia, 2022, 45-45
ISBN
978-961-93545-7-5
Skup
9th Congress of the Genetic Society of Slovenia
Mjesto i datum
Ljubljana, Slovenija, 28.09.2022. - 30.09.2022
Vrsta sudjelovanja
Pozvano predavanje
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
neuroregeneration ; transcriptomics ; proteomics ; neurodegenerative diseases ; neuronal stem cells
Sažetak
One of the major challenges of modern neurobiology concerns the inability of the adult mammalian central nervous system (CNS) to regenerate and repair itself after injury or after neuronal loss in neurodegenerative diseases. Even though our understanding of molecular and cellular mechanisms that promote or inhibit neuronal regeneration is expanding, it is still unclear what are the key differences between the neuronal systems that can and cannot regenerate, and how they can be manipulated to revert the outcome. For reasons yet unknown, with development and age, the mammalian CNS loses its capacity for functionally relevant repair after injury, as it is observed on the evolutionary scale. A convenient model to study cellular and molecular basis of this loss is neonatal opossum (Monodelphis domestica). Opossums are marsupials that are born very immature with the unique possibility to successfully regenerate postnatal spinal cord after injury in the first two weeks of their life, after which this ability abruptly stops. In the previous studies, differentially expressed genes were identified in opossum spinal cords during the critical period of development when regeneration stops being possible, revealing the molecules involved in nucleic acid management, protein synthesis and processing, control of cell growth, structure and motility, cell signaling, extracellular matrix molecules and their receptors. The transcriptomic data were upgraded with the proteomic research, to select the overlapping molecules as the most promising candidates controlling regeneration, to be tested in functional studies. Among the genes and proteins that are differentially distributed in opossum spinal tissue that can and cannot regenerate after injury, we identified the numerous proteins related to neurodegenerative diseases, such as Huntington’s, Parkinson’s, Alzheimer's disease and ALS, as well as the transcription factors that control the activity of the neuronal stem cells, such as ATF3. The identified molecules are the good candidates for further functional regenerative studies as well as potential new therapeuthic targets.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
HRZZ-IP-2016-06-7060 - Istraživanje granice između neurodegeneracije i neuroregeneracije: identifikacija ključnih molekula pomoću proteomike i funkcionalnih testova na leđnoj moždini sisavaca (DefineREgenAgeMode) (Mladinić Pejatović, Miranda, HRZZ - 2016-06) ( CroRIS)
NadSve-Sveučilište u Rijeci-uniri-biomed-18-258 6427 - Otkrivanje ključnih molekula koje kontroliraju stanične mehanizme neuroprotekcije i neuroregeneracije posredovane proteinima toplinskog stresa nakon in vitro ozljede leđne moždine oposuma (Mladinić Pejatović, Miranda, NadSve - UNIRI projekti 2018) ( CroRIS)
Ustanove:
Sveučilište u Rijeci - Odjel za biotehnologiju
Profili:
Miranda Mladinić Pejatović
(autor)
Antonela Petrović
(autor)
Jelena Ban
(autor)
Ivana Tomljanović
(autor)