Pregled bibliografske jedinice broj: 1226874
Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites
Using Copper-Doped Mesoporous Bioactive Glass Nanospheres to Impart Anti-Bacterial Properties to Dental Composites // Pharmaceutics, 14 (2022), 10; 2241, 22 doi:10.3390/pharmaceutics14102241 (međunarodna recenzija, članak, znanstveni)
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Naslov
Using Copper-Doped Mesoporous Bioactive Glass
Nanospheres to
Impart Anti-Bacterial Properties to Dental
Composites
Autori
Munir, Arooj ; Marović, Danijela ; Nogueira, Liebert Parreiras ; Simm, Roger ; Naemi, Ali-Oddin ; Landrø, Sander Marius ; Helgerud, Magnus ; Zheng, Kai ; Par, Matej ; Tauböck, Tobias T. ; Attin, Thomas ; Tarle, Zrinka ; Boccaccini, Aldo R. ; Haugen, Håvard J.
Izvornik
Pharmaceutics (1999-4923) 14
(2022), 10;
2241, 22
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
dental ; resin composites ; copper ; bioactive glass ; mesoporous ; nanoparticle ; anti-bacterial
Sažetak
Experimental dental resin composites containing copper-doped mesoporous bioactive glass nanospheres (Cu-MBGN) were developed to impart anti-bacterial properties. Increasing amounts of Cu-MBGN (0, 1, 5 and 10 wt%) were added to the BisGMA/TEGDMA resin matrix containing micro- and nano-fillers of inert glass, keeping the resin/filler ratio constant. Surface micromorphology and elemental analysis were performed to evaluate the homogeneous distribution of filler particles. The study investigated the effects of Cu-MBGN on the degree of conversion, polymerization shrinkage, porosity, ion release and anti-bacterial activity on S. mutans and A. naeslundii. Experimental materials containing Cu- MBGN showed a dose-dependent Cu release with an initial burst and a further increase after 28 days. The composite containing 10% Cu-MBGN had the best anti-bacterial effect on S. mutans, as evidenced by the lowest adherence of free-floating bacteria and biofilm formation. In contrast, the 45S5-containing materials had the highest S. mutans adherence. Ca release was highest in the bioactive control containing 15% 45S5, which correlated with the highest number of open porosities on the surface. Polymerization shrinkage was similar for all tested materials, ranging from 3.8 to 4.2%, while the degree of conversion was lower for Cu-MBGN materials. Cu- MBGN composites showed better anti-bacterial properties than composites with 45S5 BG.
Izvorni jezik
Engleski
Znanstvena područja
Dentalna medicina
POVEZANOST RADA
Projekti:
HRZZ-IP-2019-04-6183 - Biomimetički inteligentni kompozitni sustavi (BIOMICS) (Tarle, Zrinka, HRZZ - 2019-04) ( CroRIS)
Ustanove:
Stomatološki fakultet, Zagreb
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE