Naslov
Murine model of pregnancy-associated Listeria monocytogenes infection

Autori
Abram, Maja ; Schluter, Dirk ; Vučković, Darinka ; Wraber, Branka ; Dorić, Miljenko ; Deckert, Martina

Izvornik
FEMS immunology and medical microbiology (0928-8244) 35 (2003), 3; 177-182

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, pregledni rad, znanstveni

Ključne riječi
pregnancy; cytokine; mouse

Sažetak
Listeria monocytogenes has been recognized as a significant pathogen, occurring worldwide, capable of causing animal and human infections. In its most severe form, listeriosis is an invasive disease that affects immunocompromised patients. Additionally, pregnant women represent a high-risk group of L.monocytogenes infection. Abortion, stillbirth or severe neonatal infection can be the serious outcome of such an infection. In an experimental murine model of pregnancy-associated listeriosis we studied the impact of L. monocytogenes on the maternal immune response and pregnancy outcome. In comparison to virgin animals, pregnant mice mounted lower levels of protective cytokines and were inable to eliminate the pathogen. The impaired maternal immune response that has been found both on the systemic and local level, faciliated bacterial multiplication in the liver, placenta and ultimately in the fetal tissues. This resulted in severe necrotizing hemorrhagic hepatitis and Listeria-induced placental necrosis, increasing the incidence of postimplantation loss and poor pregnancy outcome.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti, Veterinarska medicina

POVEZANOST RADA