Naslov
Basic science of pain and botulinum toxin

Autori
Lacković, Zdravko ; Matak, Ivica ; Bach-Rojecky, Lidija

Vrsta, podvrsta i kategorija rada
Poglavlja u knjigama, pregledni

Knjiga
Botulinum toxin treatment in surgery, dentistry, and veterinary medicine

Urednik/ci
Jabbari, Bahman

Izdavač
Springer

Grad
Cham

Godina
2020

Raspon stranica
113-129

ISBN
978-3-030-50690-2

Ključne riječi
botulinum toxins ; pain ; CNS ; experimental models of pain ; recombinant toxins

Sažetak
The use of botulinum toxin type A (BoNT-A) in pain conditions is continuously growing largely because of its long-lasting effect after local application and safety profile. These unique features distinguish BoNT-A from other conventional and adjuvant analgesic drugs. Furthermore, BoNT-A diminishes only the pathological pain, without affecting the normal pain threshold. Preclinical data from several complex pain models suggested the central site of its action on pain after retrograde axonal transport from the peripheral site of application. Further investigations of the mechanism of BoNT-A antinociceptive action are ongoing as well as experiments on new recombinant BoNTs with higher selectivity for nociceptive neurons.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA