Pretražite po imenu i prezimenu autora, mentora, urednika, prevoditelja

Napredna pretraga

Pregled bibliografske jedinice broj: 1225571

In-situ solution concentration measurement techniques in the crystallization processes


Gavran, Matea; Bolf, Nenad; Sacher, Josip; Herceg, Srečko
In-situ solution concentration measurement techniques in the crystallization processes // IMEKO TC11 & TC24 Joint Hybrid Conference, Book of Abstract / Tomić, Tatjana ; Iannucci, Leonardo (ur.).
Cavtat: International Measurement Confederation (IMEKO), 2022. str. 63-63 (poster, međunarodna recenzija, sažetak, znanstveni)


CROSBI ID: 1225571 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
In-situ solution concentration measurement techniques in the crystallization processes
(In-situ Solution Concentration Measurement Techniques in the Crystallization Processes)

Autori
Gavran, Matea ; Bolf, Nenad ; Sacher, Josip ; Herceg, Srečko

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
IMEKO TC11 & TC24 Joint Hybrid Conference, Book of Abstract / Tomić, Tatjana ; Iannucci, Leonardo - Cavtat : International Measurement Confederation (IMEKO), 2022, 63-63

Skup
IMEKO TC11 & TC24 Joint Hybrid Conference 2022

Mjesto i datum
Dubrovnik, Hrvatska, 17.10.2022. - 19.10.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
crystallization, process analytical technology, real-time monitoring, calibration model

Sažetak
Crystallization in pharmaceutical industry is used as separation and purification process for the production of active pharmaceutical ingredients(APIs), during which multiple laboratory analysis has to be done to ensure the required product quality. Until recently, critical quality attributes (CQA), including concentration, were determined off-line, but improvements in the field of fiber optics and spectroscopic instruments has enabled in-situ measurements in real-time, eliminating manual sampling and time delay influence affecting the analysis’ outcome. In this work, overview and good laboratory practice of spectroscopic techniques for solution concentration measurement is given. Ultraviolet-visible (UV-Vis) and Fourier transform infrared (FTIR) probes work on the principle of attenuated total reflectance (ATR) so that the incident light penetrates slightly into the solution and captures only the liquid phase of the crystallization system. Even though, ATR UV-Vis is cheaper than ATR FTIR, it is limited by the UV absorption capacity of the solute and hence not suitable for compound identification. In-line Raman spectrometers have the ability to simultaneously determine both, the solution and solid concentration using only one probe. Raman data is far more complex than IR and UV-Vis data, and extracting the information on the solution concentration is challenging due to high solid’s signal. The paper presents experiences and practical examples in the application of process analytical technology (PAT) methods for real-time monitoring and control of crystallization processes. The application of PAT requires a thorough knowledge of the crystallization system, the development of calibration models utilizing artificial intelligence and the application of advanced control strategies to obtain a high-quality product.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Kemijsko inženjerstvo



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)

Profili:

Avatar Url Srečko Herceg (autor)

Avatar Url Nenad Bolf (autor)

Avatar Url Matea Gavran (autor)

Avatar Url Josip Sacher (autor)

Poveznice na cjeloviti tekst rada:

Pristup cjelovitom tekstu rada

Citiraj ovu publikaciju:

Gavran, Matea; Bolf, Nenad; Sacher, Josip; Herceg, Srečko
In-situ solution concentration measurement techniques in the crystallization processes // IMEKO TC11 & TC24 Joint Hybrid Conference, Book of Abstract / Tomić, Tatjana ; Iannucci, Leonardo (ur.).
Cavtat: International Measurement Confederation (IMEKO), 2022. str. 63-63 (poster, međunarodna recenzija, sažetak, znanstveni)
Gavran, M., Bolf, N., Sacher, J. & Herceg, S. (2022) In-situ solution concentration measurement techniques in the crystallization processes. U: Tomić, T. & Iannucci, L. (ur.)IMEKO TC11 & TC24 Joint Hybrid Conference, Book of Abstract.
@article{article, author = {Gavran, Matea and Bolf, Nenad and Sacher, Josip and Herceg, Sre\v{c}ko}, year = {2022}, pages = {63-63}, keywords = {crystallization, process analytical technology, real-time monitoring, calibration model}, title = {In-situ solution concentration measurement techniques in the crystallization processes}, keyword = {crystallization, process analytical technology, real-time monitoring, calibration model}, publisher = {International Measurement Confederation (IMEKO)}, publisherplace = {Dubrovnik, Hrvatska} }
@article{article, author = {Gavran, Matea and Bolf, Nenad and Sacher, Josip and Herceg, Sre\v{c}ko}, year = {2022}, pages = {63-63}, keywords = {crystallization, process analytical technology, real-time monitoring, calibration model}, title = {In-situ Solution Concentration Measurement Techniques in the Crystallization Processes}, keyword = {crystallization, process analytical technology, real-time monitoring, calibration model}, publisher = {International Measurement Confederation (IMEKO)}, publisherplace = {Dubrovnik, Hrvatska} }




Contrast
Increase Font
Decrease Font
Dyslexic Font