Pregled bibliografske jedinice broj: 1225571
In-situ solution concentration measurement techniques in the crystallization processes
In-situ solution concentration measurement techniques in the crystallization processes // IMEKO TC11 & TC24 Joint Hybrid Conference, Book of Abstract / Tomić, Tatjana ; Iannucci, Leonardo (ur.).
Cavtat: International Measurement Confederation (IMEKO), 2022. str. 63-63 (poster, međunarodna recenzija, sažetak, znanstveni)
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Naslov
In-situ solution concentration measurement
techniques in the crystallization processes
(In-situ Solution Concentration Measurement
Techniques in the Crystallization Processes)
Autori
Gavran, Matea ; Bolf, Nenad ; Sacher, Josip ; Herceg, Srečko
Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni
Izvornik
IMEKO TC11 & TC24 Joint Hybrid Conference, Book of Abstract
/ Tomić, Tatjana ; Iannucci, Leonardo - Cavtat : International Measurement Confederation (IMEKO), 2022, 63-63
Skup
IMEKO TC11 & TC24 Joint Hybrid Conference 2022
Mjesto i datum
Dubrovnik, Hrvatska, 17.10.2022. - 19.10.2022
Vrsta sudjelovanja
Poster
Vrsta recenzije
Međunarodna recenzija
Ključne riječi
crystallization, process analytical technology, real-time monitoring, calibration model
Sažetak
Crystallization in pharmaceutical industry is used as separation and purification process for the production of active pharmaceutical ingredients(APIs), during which multiple laboratory analysis has to be done to ensure the required product quality. Until recently, critical quality attributes (CQA), including concentration, were determined off-line, but improvements in the field of fiber optics and spectroscopic instruments has enabled in-situ measurements in real-time, eliminating manual sampling and time delay influence affecting the analysis’ outcome. In this work, overview and good laboratory practice of spectroscopic techniques for solution concentration measurement is given. Ultraviolet-visible (UV-Vis) and Fourier transform infrared (FTIR) probes work on the principle of attenuated total reflectance (ATR) so that the incident light penetrates slightly into the solution and captures only the liquid phase of the crystallization system. Even though, ATR UV-Vis is cheaper than ATR FTIR, it is limited by the UV absorption capacity of the solute and hence not suitable for compound identification. In-line Raman spectrometers have the ability to simultaneously determine both, the solution and solid concentration using only one probe. Raman data is far more complex than IR and UV-Vis data, and extracting the information on the solution concentration is challenging due to high solid’s signal. The paper presents experiences and practical examples in the application of process analytical technology (PAT) methods for real-time monitoring and control of crystallization processes. The application of PAT requires a thorough knowledge of the crystallization system, the development of calibration models utilizing artificial intelligence and the application of advanced control strategies to obtain a high-quality product.
Izvorni jezik
Engleski
Znanstvena područja
Kemija, Kemijsko inženjerstvo
POVEZANOST RADA
Projekti:
EK-EFRR-KK.01.1.1.07.0017 - Napredno vođenje procesa kristalizacije (CrystAPC) (Bolf, Nenad, EK - KK.01.1.1.07) ( CroRIS)