Naslov
Synthesis and characterization of novel hibride carbamates

Autori
Spahić, Zlatan ; Martinko, Alen ; Hrenar, Tomica ; Primožič, Ines

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Skup: 27. hrvatski skup kemičara i kemijskih inženjera s međunarodnim sudjelovanjem: Knjiga sažetaka / Marković, Dean ; Meštrović, Ernest ; Namjesnik, Danijel ; Tomašić, Vesna - Zagreb : Hrvatsko kemijsko društvo, 2021, 270-270

Skup
27. hrvatski skup kemičara i kemijskih inženjera (27HSKIKI)

Mjesto i datum
Veli Lošinj, Hrvatska, 05.10.2021. - 08.10.2021

Vrsta sudjelovanja
Poster

Vrsta recenzije
Domaća recenzija

Ključne riječi
Synthesis ; N-benzylimidazole-2-aldoxime carbamates ; stability in aqueous solutions

Sažetak
Oximes and carbamates have a wide spectrum of bioactivities. Some oximes are considered as powerful reactivators of phosphorylated cholinesterase (antidotes for organophosphorus poisoning), [1] while some carbamates are used for inhibition of cholinesterases (protection of enzyme from phosphorylation).[2] Therefore, novel hybrid oxime carbamates have been designed to serve as carbamoylating agents (protection of enzyme) as well as oxime reactivators upon reaction. A series of N-benzylimidazole-2-aldoxime carbamates have been prepared. N-alkylation of commercially available imidazole was carried out with benzyl bromide in THF with sodium hydride as a base. N-benzylimidazole was converted to 2-carbaldehyde derivative by the reaction with n-butyllithium and DMF.[3] N-benzylimidazole-2-aldoximes were synthesized using hydroxylamine hydrochloride in solution and without solvent in mechanochemical reactions.[4] In order to synthesize desired oxime carbamates appropriate carbamoyl chlorides and isocyanates were used. Structures of compounds were deduced from FTIR, ATR, one- and twodimensional NMR spectra. Stability of compounds in aqueous solutions and in organic solvents was determined.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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