Naslov
Mechanisms of Botulinum Toxin Type A Action on Pain

Autori
Matak, Ivica ; Bölcskei, Kata ; Helyes, Zsuzsanna ; Bach-Rojecky, Lidija

Izvornik
Toxins (2072-6651) 11 (2019), 8; 459, 24

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
botulinum toxin type A ; pain therapy ; migraine ; neuropathic pain ; mechanism of action

Sažetak
Already a well-established treatment for different autonomic and movement disorders, the use of botulinum toxin type A (BoNT/A) in pain conditions is now continuously expanding. Currently, the only approved use of BoNT/A in relation to pain is the treatment of chronic migraines. However, controlled clinical studies show promising results in neuropathic and other chronic pain disorders. In comparison with other conventional and non- conventional analgesic drugs, the greatest advantages of BoNT/A use are its sustained effect after a single application and its safety. Its efficacy in certain therapy-resistant pain conditions is of special importance. Novel results in recent years has led to a better understanding of its actions, although further experimental and clinical research is warranted. Here, we summarize the effects contributing to these advantageous properties of BoNT/A in pain therapy, specific actions along the nociceptive pathway, consequences of its central activities, the molecular mechanisms of actions in neurons, and general pharmacokinetic parameters.

Izvorni jezik
Engleski

POVEZANOST RADA