Naslov
Atom Economy in Synthesis of Paracetamol

Autori
Kovačević, Monika ; Samardžija, Mia ; Gašo-Sokač, Dajana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
2nd International Student GREEN Conference - Book of Abstracts / Habuda-Stanić ; Mirna - Osijek : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2022, 110-111

ISBN
978-953-7005-91-7

Skup
2. međunarodna studentska GREEN konferencija = 2nd International Students’ GREEN Conference (ISC GREEN 2022)

Mjesto i datum
Osijek, Hrvatska, 02.06.2022. - 03.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
paracetamol ; green chemistry ; green synthesis ; atomic economy

Sažetak
Paracetamol is a drug used to relieve headaches, muscle pain and to reduce body temperature. It is possible to get it by various synthetic routes from phenol, and since paracetamol is one of the most commonly used analgesics, a lot of effort is invested in developing new, environmentally friendly and more acceptable and economically viable synthetic routes. In accordance with the second principle of green chemistry synthetic methods should be designed to maximize the incorporation of all materials used in the process into the final products. One of the goals pursued under green chemistry is to increase the economy of atoms. Atom economy can be defined as the molecular weight of the isolated product divided by the sum of the molecular weights of the reactants, the result is expressed in %. Industrially, paracetamol is synthesized by nitriding phenol with sodium nitrate to form isomers of nitrophenol (ortho and para), of which o- nitrophenol is a by-product. Furthermore, the nitro group is then hydrogenated and the p- aminophenol product is acetylated with acetic anhydride. This paper describes and compares the conventional and green methods of paracetamol synthesis, with an emphasis on the green method and increase in the atomic economy. The atom economy in different methods of paracetamol synthesis varies and ranges from 36%, 38% to as much as 58%.

Izvorni jezik
Engleski

Znanstvena područja
Kemija

POVEZANOST RADA