Naslov
Relationship between vitamin D, IFN-γ, and E2 levels in systemic lupus erythematosus

Autori
Kokić, Višnja ; Martinović Kaliterna, Dušanka ; Radić, Mislav ; Perković, Dijana ; Cvek, Maja ; Ćapkun, Vesna

Izvornik
Lupus (0961-2033) 25 (2016), 3; 282-288

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Systemic lupus erythematosus ; vitamin D ; interferon-gamma ; estradiol

Sažetak
In this study, we investigated the relationship between vitamin D, interferon-gamma (IFN-g), and estradiol (E2) in females of childbearing age with inactive systemic lupus erythematosus (SLE). The study included 22 SLE patients, and 21 age- and gender-matched healthy individuals. Serum concentrations of 25-hydroxyvitamin D3 (25(OH)D3), E2, and IFN-g were measured by radioimmunoassay using the gamma-counter and ELISA. Patients and control subjects were divided into two groups based on their vitamin D levels (25(OH)D3 20 ng/ mL ; 25(OH)D3> 20 ng/mL). The median values of IFN- g and E2 were higher in SLE patients compared to the controls, irrespective of vitamin D level (p ¼ 0.001, p ¼ 0.009, p ¼ 0.003, and p ¼ 0.003, respectively). In SLE patients, there was a negative correlation between IFN-g and 25(OH)D3 (rs ¼ 0.330 ; p ¼ 0.03) and a positive correlation between IFN-g and E2 (rs ¼ 0.404 ; p ¼ 0.007). This study demonstrates an interesting interplay between vitamin D, INF-g, and E2 in SLE patients with inactive disease.

Izvorni jezik
Engleski

Znanstvena područja
Javno zdravstvo i zdravstvena zaštita

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