Naslov
Is postoperative cognitive decline after cardiac surgery associated with plasma beta amyloid 1-42 levels?
(Is postoperative cognitive decline after cardiac surgery associated with plasma beta amyloid 1-42 levels)

Autori
Požgain, Zrinka ; Dulić, Grgur ; Kondža, Goran ; Bogović, Siniša ; Šerić, Ivan ; Hil, Dejan ; Trogrlić, Bojan ; Bednjanić, Ana ; Perković-Kovačević, Marina ; Šahinović, Ines

Izvornik
Journal of Cardiothoracic Surgery (1749-8090) 17 (2022), 6; 10.1186/s13019-022-01755-4, 8

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Amyloid fibrils ; Cognitive decline ; Coronary artery bypass surgery

Sažetak
Background: Postoperative cognitive decline following cardiac surgery is one of the frequently reported complica‑tions affecting postoperative outcome, characterized by impairment of memory or concentration. The aetiology is considered multifactorial and the research conducted so far has presented contradictory results. The proposed mechanisms to explain the cognitive decline associated with cardiac surgery include the neurotoxic accumulation of β‑amyloid (Aβ) proteins similar to Alzheimer’s disease. The comparison of coronary artery bypass grafting procedures concerning postoperative cognitive decline and plasmatic Aβ1‑42 concentrations has not yet been conducted.Methods:The research was designed as a controlled clinical study of patients with coronary artery disease undergo‑ing surgical myocardial revascularization with or without the use of a cardiopulmonary bypass machine. All patients completed a battery of neuropsychological tests and plasmatic Aβ1‑42 concentrations were collected.Results:The neuropsychological test results postoperatively were significantly worse in the cardiopulmonary bypass group and the patients had larger shifts in the Aβ1‑42 preoperative and postoperative values than the group in which off‑pump coronary artery bypass was performed.Conclusions:The conducted research confirmed the earlier suspected association of plasmatic Aβ1‑42 concentra‑tion to postoperative cognitive decline and the results further showed that there were less changes and lower con‑centrations in the off‑pump coronary artery bypass group, which correlated to less neurocognitive decline. There is a lot of clinical contribution acquired by this research, not only in everyday decision making and using amyloid proteins as biomarkers, but also in the development and application of non‑pharmacological and pharmacological neuropro‑tective strategies.

Izvorni jezik
Engleski

POVEZANOST RADA