Naslov
Sinteza derivata kinazolinona primjenom odabranih zelenih metoda i njihova potencijalna antibakterijska aktivnost
(Synthesis of quinazolinone derivatives using selected green chemistry methods and their potential antibacterial activity)

Autori
Prašnikar, Fran ; Komar, Mario ; Pavić, Valentina ; Molnar, Maja

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts 19th Ružička days Today Science - Tomorrow Industry / Babić, Jurislav - Osijek : Zagreb : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku ; Hrvatsko društvo kemijskih inženjera i tehnologa (HDKI), 2022, 41-41

Skup
19. Ružičkini dani "Danas znanost - sutra industrija"

Mjesto i datum
Vukovar, Hrvatska, 21.09.2022. - 23.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
Zelena kemija, derivati kinazolinona, eutektička otapala, antibakterijska aktivnost
(Green chemistry, quinazolinone derivatives, deep eutectic solvents, antibacterial activity)

Sažetak
One of the main advantages of green chemistry is the tendency to develop procedures and techniques with low environmental impact. Deep eutectic solvents (DESs) have become an important part of organic synthesis due to their properties. Different quinazolinones were synthesized in choline chloride: urea (1: 2) DES using microwave-assisted and ultrasound-assisted synthesis. First, optimization was performed to find the appropriate DES, time of reaction and temperature. Starting compounds for the quinazolinone synthesis were differently substituted anthranilic acids, anilines and trimethyl orthoformate. The most appropriate method for synthesis was microwave-assisted synthesis using ethanol as a solvent. The antibacterial activity of quinazolinone derivatives was studied by minimal inhibitory concentration. All derivatives have shown antibacterial activity.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Biologija, Prehrambena tehnologija

POVEZANOST RADA