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Pregled bibliografske jedinice broj: 1224632

Human neutrophil antigen‐1, ‐3, ‐4, and ‐5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance

Stimac, R.; Tomicic, M.; Bingulac-Popovic, J.; Kundid, R.; Babic, I.; Hecimovic, A.; Vuk, T.; Jukic, I.
Human neutrophil antigen‐1, ‐3, ‐4, and ‐5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance // Transfusion Clinique et Biologique (2022) doi:10.1016/j.tracli.2022.10.001 (znanstveni, online first)

CROSBI ID: 1224632 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Human neutrophil antigen‐1, ‐3, ‐4, and ‐5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance

Autori
Stimac, R. ; Tomicic, M. ; Bingulac-Popovic, J. ; Kundid, R. ; Babic, I. ; Hecimovic, A. ; Vuk, T. ; Jukic, I.

Vrsta, podvrsta
Radovi u časopisima, znanstveni

Izvornik
Transfusion Clinique et Biologique (2022)

Status rada
Online first

Ključne riječi
Human neutrophil antigen ; HNA ; Polymerase chain reaction ; PCR-SSP ; genotyping

Sažetak
Objectives Human neutrophil antigens (HNAs) and antibodies play an important role in allo- and autoimmunity associated with immune neutropenia and transfusion reactions. The aim of this study was to determine the HNA-1, -3, -4 and -5 allele and genotype frequencies in the Croatian blood donor population to assess the role of HNA-1, -3, -4, and -5 alleles in the development of neonatal alloimmune neutropenia and antibody-mediated transfusion- related acute lung injury. Material and methods A total of 371 blood samples from unselected healthy blood donors were analyzed. Samples from all 371 donors were genotyped for HNA-1, samples from 160 donors were genotyped for HNA-3, and samples from 142 donors were genotyped for HNA-4 and HNA-5 using the polymerase chain reaction with sequence-specific primers (PCR-SSP) method. Results The frequencies of the FCGR3B*01, FCGR3B*02 and FCGR3B*03 HNA-1 alleles were 0.393, 0.607 and 0.022, and of the SLC44A2*01 and SLC44A2*02 HNA-3 alleles 0.781 and 0.219, respectively. The frequencies of the ITGAM*01 and ITGAM*02 HNA-4 alleles were 0.796 and 0.204, and of the ITGAL*01 and ITGAL*02 HNA-5 alleles 0.718 and 0.282, respectively. Conclusion These are the first results on the HNA allele and genotype frequencies in the Croatian blood donor population. We observed no deviations from previous reports on Caucasian populations. Determination of the HNA antigen frequencies in the population is important to estimate the risk of alloimmunization to HNA, especially the risk of fetal-maternal incompatibility and alloantibody production by transfusion of the HNA incompatible blood components.

Izvorni jezik
Engleski



POVEZANOST RADA

Ustanove:
Hrvatski zavod za transfuzijsku medicinu,
Medicinski fakultet, Osijek

Profili:

Avatar Url Ružica Štimac (autor)

Avatar Url Irena Jukić (autor)

Avatar Url Maja Tomičić (autor)

Avatar Url Ivana Babić (autor)

Avatar Url Tomislav Vuk (autor)

Avatar Url Ana Hećimović (autor)

Avatar Url Jasna Bingulac-Popović (autor)

Poveznice na cjeloviti tekst rada:

doi

Citiraj ovu publikaciju:

Stimac, R.; Tomicic, M.; Bingulac-Popovic, J.; Kundid, R.; Babic, I.; Hecimovic, A.; Vuk, T.; Jukic, I.
Human neutrophil antigen‐1, ‐3, ‐4, and ‐5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance // Transfusion Clinique et Biologique (2022) doi:10.1016/j.tracli.2022.10.001 (znanstveni, online first)
Stimac, R., Tomicic, M., Bingulac-Popovic, J., Kundid, R., Babic, I., Hecimovic, A., Vuk, T. & Jukic, I. (2022) Human neutrophil antigen‐1, ‐3, ‐4, and ‐5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance. Prihvaćen za objavljivanje u Transfusion Clinique et Biologique. [Preprint] doi:10.1016/j.tracli.2022.10.001.
@unknown{unknown, author = {Stimac, R. and Tomicic, M. and Bingulac-Popovic, J. and Kundid, R. and Babic, I. and Hecimovic, A. and Vuk, T. and Jukic, I.}, year = {2022}, DOI = {10.1016/j.tracli.2022.10.001}, keywords = {Human neutrophil antigen, HNA, Polymerase chain reaction, PCR-SSP, genotyping}, journal = {Transfusion Clinique et Biologique}, doi = {10.1016/j.tracli.2022.10.001}, title = {Human neutrophil antigen‐1, ‐3, ‐4, and ‐5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance}, keyword = {Human neutrophil antigen, HNA, Polymerase chain reaction, PCR-SSP, genotyping} }
@unknown{unknown, author = {Stimac, R. and Tomicic, M. and Bingulac-Popovic, J. and Kundid, R. and Babic, I. and Hecimovic, A. and Vuk, T. and Jukic, I.}, year = {2022}, DOI = {10.1016/j.tracli.2022.10.001}, keywords = {Human neutrophil antigen, HNA, Polymerase chain reaction, PCR-SSP, genotyping}, journal = {Transfusion Clinique et Biologique}, doi = {10.1016/j.tracli.2022.10.001}, title = {Human neutrophil antigen‐1, ‐3, ‐4, and ‐5 allele and genotype frequencies in the Croatian blood donor population and their clinical significance}, keyword = {Human neutrophil antigen, HNA, Polymerase chain reaction, PCR-SSP, genotyping} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE

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