Pregled bibliografske jedinice broj: 1224522
Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis
Psychiatric Illness or Immune Dysfunction—Brain Perfusion Imaging Providing the Answer in a Case of Anti-NMDAR Encephalitis // Diagnostics, 12 (2022), 10; 2377, 10 doi:10.3390/ diagnostics12102377 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1224522 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Psychiatric Illness or Immune Dysfunction—Brain
Perfusion
Imaging Providing the Answer in a Case of
Anti-NMDAR Encephalitis
Autori
Šiško Markoš, Ines ; Blažeković, Ivan ; Peitl, Vjekoslav ; Jukić, Tomislav ; Supanc, Višnja ; Karlović, Dalibor ; Fröbe, Ana.
Izvornik
Diagnostics (2075-4418) 12
(2022), 10;
2377, 10
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
anti-NMDAR encephalitis ; SPECT ; quantification ; schizophrenia
Sažetak
Background: We investigated the potential use of SPECT quantification in addition to qualitative brain perfusion analysis for the detection of anti-NMDAR encephalitis. The question is how to normalize brain activity to be able to quantitatively detect perfusion patterns. Usually, brain activity is normalized to a structure considered unaffected by the disease. Methods: Brain [99mTc]- HMPAO SPECT was performed as a method to detect brain perfusion patterns. The patterns of abnormal brain perfusion cannot always be reliably and qualitatively assessed when dealing with rare diseases. Recent advances in SPECT quantification using commercial software have enabled more objective and detailed analysis of brain perfusion. The cerebellum and whole brain were used as the normalization structures and were compared with visual analysis. Results: The quantification analysis performed with whole brain normalization confirmed right parietal lobe hypoperfusion while also detecting statistically significant left-to-right perfusion differences between the temporal lobe and thalamus. Whole brain normalization further described bilateral frontal lobe hyperperfusion, predominantly of the left lobe, and was in accordance with visual analysis. Conclusion: SPECT quantitative brain perfusion analysis, using the whole brain as the normalization structure rather than the cerebellum, in this case, improved confidence in the visualdetection of anti-NMDAR encephalitis and provided unexpected solutions to atypical psychiatric dilemmas.
Izvorni jezik
Engleski
Znanstvena područja
Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Ustanove:
Stomatološki fakultet, Zagreb,
Medicinski fakultet, Zagreb,
KBC "Sestre Milosrdnice",
Hrvatsko katoličko sveučilište, Zagreb
Profili:
Ivan Blažeković (autor)
Dalibor Karlović (autor)
Tomislav Jukić (autor)
INES ŠIŠKO MARKOŠ (autor)
Ana Fröbe (autor)
Višnja Supanc (autor)
Vjekoslav Peitl (autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus