Naslov
Quaternization Reactions of Isonicotinamide According to the Principles of Green Chemistry

Autori
Tomičić, Vice ; Bušić, Valentina

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
Book of Abstracts ISC GREEN 2022 2 Internactional Student Green Conference / Habuda-Stanić, Mirna - Osijek : Prehrambeno tehnološki fakultet Sveučilišta Josipa Jurja Strossmayera u Osijeku, 2022, 115-115

ISBN
978-953-7005-91-7

Skup
2. međunarodna studentska GREEN konferencija = 2nd International Students’ GREEN Conference (ISC GREEN 2022)

Mjesto i datum
Osijek, Hrvatska, 02.06.2022. - 03.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
green chemistry ; eutectic solvents ; isonicotinamide derivatives, ultrasound synthesis

Sažetak
Green chemistry is the chemistry that designs chemical processes and products using greener, more environmentally benign solvents. It maximizes products, minimizes by-products and simplifies processes leading to reduced energy consumption. The Menshutkin reaction is a reaction by which tertiary amines are converted to quaternary salts. In this SN2 reaction, the neutral reactants are converted to charged products. Most organic solvents used in the conventional synthesis of pyridinium quaternary salts are volatile, hazardous, toxic like acetone and anhydrous dimethylformamide, anhydrous benzene, acetonitrile, etc. According to the 12 principles of green chemistry we tried to focus our research on the use of safer and more environmentally friendly solvents – deep eutectic solvents. The quaternization reactions of isonicotinamide with substituted 2-bromoacetophenones (4-F, 4-Br, 4-Ph, 4-OCH3, 4-NO2) were performed. Both conventional and ultrasound methods were successfully performed. The ultrasound method gave similar yields as the conventional method. The highest yield was obtained by the conventional method in the quaternization reaction of isonicotinamide and 2-bromo-4'-phenylacetophenone in the eutectic solvent choline chloride: oxalic acid 1: 1 (96%), while in the same eutectic solvent by the ultrasonic method in the quaternisation reaction 2- bromine-4'-phenylacetophenone the highest yield achieved (94%).

Izvorni jezik
Engleski

Znanstvena područja
Kemija

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