Naslov
GSTP1 as diagnostic marker in prostate cancer

Autori
Mulabdić, Denis ; Škara, Lucija ; Tomić, Miroslav ; Tomašković, Igor ; Tomas, Davor ; Ulamec, Monika

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Skup
28th Ljudevit Jurak International Symposium on Comparative Pathology with One Health Session

Mjesto i datum
Zagreb, Hrvatska, 10.06.2022. - 11.06.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Recenziran

Ključne riječi
GSTP1, prostate cancer

Sažetak
Prostate cancer (PCa) research is focused on finding more accurate diagnostic and prognostic tools in the diagnosis of PCa. Early PCa identification is paramount in the prevention of metastatic progression as well as treatment in its initial stages. Low specificity of the routinely used diagnostic biomarker - prostate specific antigen (PSA) leads to excessive biopsies and generates an unnecessary financial burden on the health system. Gene panel biomarkers such as the Gluthathione S Transferase P1 (GSTP1) are currently the focus of intense research as a site of aberrant modification in PCa. GSTP1 is overexpressed in solid tumours including renal and urinary carcinomas and is associated with therapeutic failures of chemotherapy, cancer drug resistance and a poorer prognosis. In our study we compared immunohistochemical expression of GSTP1 in 20 PCa patients with 20 benign hyperplasia (BPH) patients. Expression was analyzed in PCa and BPH epithelial cells, as well as in stromal cells. Expression of GSTP1 was completely lost in the PCa epithelia and preserved in BPH. Furthermore, while expression in the stroma was higher in PCa, it was not deemed statistically relevant. We conclude that GSTP1 has a potential as the diagnostic PCa marker but further studies with the larger cohorts are needed.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti

POVEZANOST RADA