Pregled bibliografske jedinice broj: 1223941
Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease
Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease // Diabetes care, 45 (2022), 11; 2729-2736 doi:10.2337/dc22-0833 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1223941 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
Immunoglobulin G N-glycosylation signatures in
incident type 2 diabetes and cardiovascular disease
Autori
Birukov, Anna ; Plavša, Branimir ; Eichelmann, Fabian ; Kuxhaus, Olga ; Hoshi, Rosangela Akemi ; Rudman, Najda ; Štambuk, Tamara ; Trbojević- Akmačić, Irena ; Schiborn, Catarina ; Morze, Jakub ; Mihelčić, Matea ; Cindrić, Ana ; Liu, Yanyan ; Demler, Olga ; Perola, Markus ; Mora, Samia ; Schulze, Matthias B. ; Lauc, Gordan ; Wittenbecher, Clemens
Izvornik
Diabetes care (0149-5992) 45
(2022), 11;
2729-2736
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
N-glycosylation, immunoglobulin G, type 2 diabetes, CVD
Sažetak
OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS We performed case-cohort studies within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)– Potsdam cohort (2, 127 in the type 2 diabetes subcohort [741 incident cases] ; 2, 175 in the CVD subcohort [417 myocardial infarction and stroke cases]). Relative abundances of 24 IgG N-glycan peaks (IgG-GPs) were measured by ultraperformance liquid chromatography, and eight glycosylation traits were derived based on structural similarity. End point–associated IgG-GPs were preselected with fractional polynomials, and prospective associations were estimated in confounder-adjusted Cox models. Diabetes risk associations were validated in three independent studies. RESULTS After adjustment for confounders and multiple testing correction, IgG-GP7, IgG-GP8, IgG-GP9, IgG-GP11, and IgG-GP19 were associated with type 2 diabetes risk. A score based on these IgG-GPs was associated with a higher diabetes risk in EPIC- Potsdam and independent validation studies (843 total cases, 3, 149 total non-cases, pooled estimate per SD increase 1.50 [95% CI 1.37– 1.64]). Associations of IgG-GPs with CVD risk differed between men and women. In women, IgG-GP9 was inversely associated with CVD risk (hazard ratio [HR] per SD 0.80 [95% CI 0.65–0.98]). In men, a weighted score based on IgG-GP19 and IgG- GP23 was associated with higher CVD risk (HR per SD 1.47 [95% CI 1.20–1.80]). In addition, several derived traits were associated with cardiometabolic disease incidence. CONCLUSIONS Selected IgG N-glycans are associated with cardiometabolic risk beyond classic risk factors, including clinical biomarkers.
Izvorni jezik
Engleski
Znanstvena područja
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)
POVEZANOST RADA
Projekti:
EK-EFRR-KK.01.2.2.03.0006 - Centar kompetencija u molekularnoj dijagnostici (CEKOM) (Knjaz, Damir; Lauc, Gordan; Vugrek, Oliver; Polašek, Ozren, EK - KK.01.2.2.03) ( CroRIS)
EK-KF-KK.01.1.1.01.0010 - Znanstveni centar izvrsnosti za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Polašek, Ozren; Secenji, Aleksandar, EK ) ( CroRIS)
EK-EFRR-KK.01.2.1.01.0003 - Nova generacija visokoprotočnih glikoservisa (Lauc, Gordan; Gornik Kljaić, Olga; Zoldoš, Vlatka, EK - Poziv na dostavu projektnih prijedloga „Povećanje razvoja novih proizvoda i usluga koji proizlaze iz aktivnosti istraživanja i razvoja“) ( CroRIS)
EK-H2020-722095 - Exploitation of Glycosylation Signatures for Precision Medicine (GlySign) (EK - H2020-MSCA-ITN-2016) ( CroRIS)
Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.
Profili:
Gordan Lauc
(autor)
Branimir Plavša
(autor)
Tamara Štambuk
(autor)
Najda Rudman
(autor)
Ana Cindrić
(autor)
IRENA TRBOJEVIĆ AKMAČIĆ
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE