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Pregled bibliografske jedinice broj: 1223941

Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease


Birukov, Anna; Plavša, Branimir; Eichelmann, Fabian; Kuxhaus, Olga; Hoshi, Rosangela Akemi; Rudman, Najda; Štambuk, Tamara; Trbojević- Akmačić, Irena; Schiborn, Catarina; Morze, Jakub et al.
Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease // Diabetes care, 45 (2022), 11; 2729-2736 doi:10.2337/dc22-0833 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1223941 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease

Autori
Birukov, Anna ; Plavša, Branimir ; Eichelmann, Fabian ; Kuxhaus, Olga ; Hoshi, Rosangela Akemi ; Rudman, Najda ; Štambuk, Tamara ; Trbojević- Akmačić, Irena ; Schiborn, Catarina ; Morze, Jakub ; Mihelčić, Matea ; Cindrić, Ana ; Liu, Yanyan ; Demler, Olga ; Perola, Markus ; Mora, Samia ; Schulze, Matthias B. ; Lauc, Gordan ; Wittenbecher, Clemens

Izvornik
Diabetes care (0149-5992) 45 (2022), 11; 2729-2736

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
N-glycosylation, immunoglobulin G, type 2 diabetes, CVD

Sažetak
OBJECTIVE N-glycosylation is a functional posttranslational modification of immunoglobulins (Igs). We hypothesized that specific IgG N-glycans are associated with incident type 2 diabetes and cardiovascular disease (CVD). RESEARCH DESIGN AND METHODS We performed case-cohort studies within the population-based European Prospective Investigation into Cancer and Nutrition (EPIC)– Potsdam cohort (2, 127 in the type 2 diabetes subcohort [741 incident cases] ; 2, 175 in the CVD subcohort [417 myocardial infarction and stroke cases]). Relative abundances of 24 IgG N-glycan peaks (IgG-GPs) were measured by ultraperformance liquid chromatography, and eight glycosylation traits were derived based on structural similarity. End point–associated IgG-GPs were preselected with fractional polynomials, and prospective associations were estimated in confounder-adjusted Cox models. Diabetes risk associations were validated in three independent studies. RESULTS After adjustment for confounders and multiple testing correction, IgG-GP7, IgG-GP8, IgG-GP9, IgG-GP11, and IgG-GP19 were associated with type 2 diabetes risk. A score based on these IgG-GPs was associated with a higher diabetes risk in EPIC- Potsdam and independent validation studies (843 total cases, 3, 149 total non-cases, pooled estimate per SD increase 1.50 [95% CI 1.37– 1.64]). Associations of IgG-GPs with CVD risk differed between men and women. In women, IgG-GP9 was inversely associated with CVD risk (hazard ratio [HR] per SD 0.80 [95% CI 0.65–0.98]). In men, a weighted score based on IgG-GP19 and IgG- GP23 was associated with higher CVD risk (HR per SD 1.47 [95% CI 1.20–1.80]). In addition, several derived traits were associated with cardiometabolic disease incidence. CONCLUSIONS Selected IgG N-glycans are associated with cardiometabolic risk beyond classic risk factors, including clinical biomarkers.

Izvorni jezik
Engleski

Znanstvena područja
Biologija, Biotehnologija u biomedicini (prirodno područje, biomedicina i zdravstvo, biotehničko područje)



POVEZANOST RADA


Projekti:
EK-EFRR-KK.01.2.2.03.0006 - Centar kompetencija u molekularnoj dijagnostici (CEKOM) (Knjaz, Damir; Lauc, Gordan; Vugrek, Oliver; Polašek, Ozren, EK - KK.01.2.2.03) ( CroRIS)
EK-KF-KK.01.1.1.01.0010 - Znanstveni centar izvrsnosti za personaliziranu brigu o zdravlju (ZCIPersonHealth) (Polašek, Ozren; Secenji, Aleksandar, EK ) ( CroRIS)
EK-EFRR-KK.01.2.1.01.0003 - Nova generacija visokoprotočnih glikoservisa (Lauc, Gordan; Gornik Kljaić, Olga; Zoldoš, Vlatka, EK - Poziv na dostavu projektnih prijedloga „Povećanje razvoja novih proizvoda i usluga koji proizlaze iz aktivnosti istraživanja i razvoja“) ( CroRIS)
EK-H2020-722095 - Exploitation of Glycosylation Signatures for Precision Medicine (GlySign) (EK - H2020-MSCA-ITN-2016) ( CroRIS)

Ustanove:
Farmaceutsko-biokemijski fakultet, Zagreb,
GENOS d.o.o.

Poveznice na cjeloviti tekst rada:

doi diabetesjournals.org

Citiraj ovu publikaciju:

Birukov, Anna; Plavša, Branimir; Eichelmann, Fabian; Kuxhaus, Olga; Hoshi, Rosangela Akemi; Rudman, Najda; Štambuk, Tamara; Trbojević- Akmačić, Irena; Schiborn, Catarina; Morze, Jakub et al.
Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease // Diabetes care, 45 (2022), 11; 2729-2736 doi:10.2337/dc22-0833 (međunarodna recenzija, članak, znanstveni)
Birukov, A., Plavša, B., Eichelmann, F., Kuxhaus, O., Hoshi, R., Rudman, N., Štambuk, T., Trbojević- Akmačić, I., Schiborn, C. & Morze, J. (2022) Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease. Diabetes care, 45 (11), 2729-2736 doi:10.2337/dc22-0833.
@article{article, author = {Birukov, Anna and Plav\v{s}a, Branimir and Eichelmann, Fabian and Kuxhaus, Olga and Hoshi, Rosangela Akemi and Rudman, Najda and \v{S}tambuk, Tamara and Trbojevi\'{c}- Akma\v{c}i\'{c}, Irena and Schiborn, Catarina and Morze, Jakub and Mihel\v{c}i\'{c}, Matea and Cindri\'{c}, Ana and Liu, Yanyan and Demler, Olga and Perola, Markus and Mora, Samia and Schulze, Matthias B. and Lauc, Gordan and Wittenbecher, Clemens}, year = {2022}, pages = {2729-2736}, DOI = {10.2337/dc22-0833}, keywords = {N-glycosylation, immunoglobulin G, type 2 diabetes, CVD}, journal = {Diabetes care}, doi = {10.2337/dc22-0833}, volume = {45}, number = {11}, issn = {0149-5992}, title = {Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease}, keyword = {N-glycosylation, immunoglobulin G, type 2 diabetes, CVD} }
@article{article, author = {Birukov, Anna and Plav\v{s}a, Branimir and Eichelmann, Fabian and Kuxhaus, Olga and Hoshi, Rosangela Akemi and Rudman, Najda and \v{S}tambuk, Tamara and Trbojevi\'{c}- Akma\v{c}i\'{c}, Irena and Schiborn, Catarina and Morze, Jakub and Mihel\v{c}i\'{c}, Matea and Cindri\'{c}, Ana and Liu, Yanyan and Demler, Olga and Perola, Markus and Mora, Samia and Schulze, Matthias B. and Lauc, Gordan and Wittenbecher, Clemens}, year = {2022}, pages = {2729-2736}, DOI = {10.2337/dc22-0833}, keywords = {N-glycosylation, immunoglobulin G, type 2 diabetes, CVD}, journal = {Diabetes care}, doi = {10.2337/dc22-0833}, volume = {45}, number = {11}, issn = {0149-5992}, title = {Immunoglobulin G N-glycosylation signatures in incident type 2 diabetes and cardiovascular disease}, keyword = {N-glycosylation, immunoglobulin G, type 2 diabetes, CVD} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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