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Pregled bibliografske jedinice broj: 1223751

Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis


Bilić, Petra; Horvatić, Anita; Kuleš, Josipa; Gelemanović, Andrea; Beer Ljubić, Blanka; Mũnoz- Prieto, Alberto; Gotić, Jelena; Žubčić, Damir; Barić Rafaj, Renata; Mrljak, Vladimir
Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis // Journal of Proteomics, 270 (2023), 104735, 12 doi:10.1016/j.jprot.2022.104735 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1223751 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis

Autori
Bilić, Petra ; Horvatić, Anita ; Kuleš, Josipa ; Gelemanović, Andrea ; Beer Ljubić, Blanka ; Mũnoz- Prieto, Alberto ; Gotić, Jelena ; Žubčić, Damir ; Barić Rafaj, Renata ; Mrljak, Vladimir

Izvornik
Journal of Proteomics (1874-3919) 270 (2023); 104735, 12

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
Babesiosis ; Serum ; Urine ; Quantitative proteomics ; Tandem mass tag ; Kidney dysfunction

Sažetak
Canine babesiosis is a tick-borne disease caused by Babesia canis, with acute kidney injury as one of the common complications. In the study 8 healthy control dogs and 22 dogs with naturally occurring babesiosis were enrolled, with the aim to analyse differences in serum and urinary proteomes between healthy dogs and dogs with different degree of renal dysfunction in babesiosis using a label-based high-throughput quantitative proteomic approach. In serum, 58 proteins were found differentially abundant between healthy controls and groups of dogs with different degrees of renal dysfunction in babesiosis, while in urine there were 259 differentially abundant proteins. In addition, altered biological pathways were detected in the diseased dogs using bioinformatics tools and validation of several candidate biomarkers was performed.

Izvorni jezik
Engleski

Znanstvena područja
Veterinarska medicina



POVEZANOST RADA


Projekti:
HRZZ-IP-2013-11-4135 - Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasa (BioDog) (Mrljak, Vladimir, HRZZ - 2013-11) ( CroRIS)
EK-FP7-621394 - Upgrading the research performance in molecular medicine at the Faculty of Veterinary Medicine University of Zagreb (VETMEDZG) (EK - FP7-ERAChairs-PilotCall-2013) ( CroRIS)

Ustanove:
Veterinarski fakultet, Zagreb,
Prehrambeno-biotehnološki fakultet, Zagreb,
Mediteranski institut za istraživanje života

Poveznice na cjeloviti tekst rada:

doi www.sciencedirect.com

Citiraj ovu publikaciju:

Bilić, Petra; Horvatić, Anita; Kuleš, Josipa; Gelemanović, Andrea; Beer Ljubić, Blanka; Mũnoz- Prieto, Alberto; Gotić, Jelena; Žubčić, Damir; Barić Rafaj, Renata; Mrljak, Vladimir
Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis // Journal of Proteomics, 270 (2023), 104735, 12 doi:10.1016/j.jprot.2022.104735 (međunarodna recenzija, članak, znanstveni)
Bilić, P., Horvatić, A., Kuleš, J., Gelemanović, A., Beer Ljubić, B., Mũnoz- Prieto, A., Gotić, J., Žubčić, D., Barić Rafaj, R. & Mrljak, V. (2023) Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis. Journal of Proteomics, 270, 104735, 12 doi:10.1016/j.jprot.2022.104735.
@article{article, author = {Bili\'{c}, Petra and Horvati\'{c}, Anita and Kule\v{s}, Josipa and Gelemanovi\'{c}, Andrea and Beer Ljubi\'{c}, Blanka and M\~{u}noz- Prieto, Alberto and Goti\'{c}, Jelena and \v{Z}ub\v{c}i\'{c}, Damir and Bari\'{c} Rafaj, Renata and Mrljak, Vladimir}, year = {2023}, pages = {12}, DOI = {10.1016/j.jprot.2022.104735}, chapter = {104735}, keywords = {Babesiosis, Serum, Urine, Quantitative proteomics, Tandem mass tag, Kidney dysfunction}, journal = {Journal of Proteomics}, doi = {10.1016/j.jprot.2022.104735}, volume = {270}, issn = {1874-3919}, title = {Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis}, keyword = {Babesiosis, Serum, Urine, Quantitative proteomics, Tandem mass tag, Kidney dysfunction}, chapternumber = {104735} }
@article{article, author = {Bili\'{c}, Petra and Horvati\'{c}, Anita and Kule\v{s}, Josipa and Gelemanovi\'{c}, Andrea and Beer Ljubi\'{c}, Blanka and M\~{u}noz- Prieto, Alberto and Goti\'{c}, Jelena and \v{Z}ub\v{c}i\'{c}, Damir and Bari\'{c} Rafaj, Renata and Mrljak, Vladimir}, year = {2023}, pages = {12}, DOI = {10.1016/j.jprot.2022.104735}, chapter = {104735}, keywords = {Babesiosis, Serum, Urine, Quantitative proteomics, Tandem mass tag, Kidney dysfunction}, journal = {Journal of Proteomics}, doi = {10.1016/j.jprot.2022.104735}, volume = {270}, issn = {1874-3919}, title = {Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis}, keyword = {Babesiosis, Serum, Urine, Quantitative proteomics, Tandem mass tag, Kidney dysfunction}, chapternumber = {104735} }

Časopis indeksira:


  • Current Contents Connect (CCC)
  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


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