Pregled bibliografske jedinice broj: 1223751
Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis
Serum and urine profiling by high-throughput TMT- based proteomics for the investigation of renal dysfunction in canine babesiosis // Journal of Proteomics, 270 (2023), 104735, 12 doi:10.1016/j.jprot.2022.104735 (međunarodna recenzija, članak, znanstveni)
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Naslov
Serum and urine profiling by high-throughput TMT-
based proteomics for the investigation of renal
dysfunction in canine babesiosis
Autori
Bilić, Petra ; Horvatić, Anita ; Kuleš, Josipa ; Gelemanović, Andrea ; Beer Ljubić, Blanka ; Mũnoz- Prieto, Alberto ; Gotić, Jelena ; Žubčić, Damir ; Barić Rafaj, Renata ; Mrljak, Vladimir
Izvornik
Journal of Proteomics (1874-3919) 270
(2023);
104735, 12
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
Babesiosis ; Serum ; Urine ; Quantitative proteomics ; Tandem mass tag ; Kidney dysfunction
Sažetak
Canine babesiosis is a tick-borne disease caused by Babesia canis, with acute kidney injury as one of the common complications. In the study 8 healthy control dogs and 22 dogs with naturally occurring babesiosis were enrolled, with the aim to analyse differences in serum and urinary proteomes between healthy dogs and dogs with different degree of renal dysfunction in babesiosis using a label-based high-throughput quantitative proteomic approach. In serum, 58 proteins were found differentially abundant between healthy controls and groups of dogs with different degrees of renal dysfunction in babesiosis, while in urine there were 259 differentially abundant proteins. In addition, altered biological pathways were detected in the diseased dogs using bioinformatics tools and validation of several candidate biomarkers was performed.
Izvorni jezik
Engleski
Znanstvena područja
Veterinarska medicina
POVEZANOST RADA
Projekti:
HRZZ-IP-2013-11-4135 - Proteomski pristup otkrivanju biomarkera ranog oštećenja bubrega i srca u pasa (BioDog) (Mrljak, Vladimir, HRZZ - 2013-11) ( CroRIS)
EK-FP7-621394 - Upgrading the research performance in molecular medicine at the Faculty of Veterinary Medicine University of Zagreb (VETMEDZG) (EK - FP7-ERAChairs-PilotCall-2013) ( CroRIS)
Ustanove:
Veterinarski fakultet, Zagreb,
Prehrambeno-biotehnološki fakultet, Zagreb,
Mediteranski institut za istraživanje života
Profili:
Renata Barić-Rafaj
(autor)
Andrea Gelemanović
(autor)
Blanka Beer Ljubić
(autor)
Anita Horvatić
(autor)
Vladimir Mrljak
(autor)
Petra Nižić
(autor)
Damir Žubčić
(autor)
Jelena Gotić
(autor)
Josipa Kuleš
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Current Contents Connect (CCC)
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE