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Pregled bibliografske jedinice broj: 1223291

SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study


Brlić, Paola Kučan; Pavletić, Martina; Lerga, Mate; Krstanović, Fran; Matešić, Marina Pribanić; Miklić, Karmela; Malić, Suzana; Mikša, Leonarda; Pajcur, Maja; Peruč, Dolores et al.
SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study // Viruses, 14 (2022), 9; 2-22 doi:10.3390/v14091966 (međunarodna recenzija, članak, znanstveni)


CROSBI ID: 1223291 Za ispravke kontaktirajte CROSBI podršku putem web obrasca

Naslov
SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study

Autori
Brlić, Paola Kučan ; Pavletić, Martina ; Lerga, Mate ; Krstanović, Fran ; Matešić, Marina Pribanić ; Miklić, Karmela ; Malić, Suzana ; Mikša, Leonarda ; Pajcur, Maja ; Peruč, Dolores ; Schubert, Maren ; Bertoglio, Federico ; Arapović, Jurica ; Protić, Alen ; Šustić, Alan ; Milošević, Marko ; Šain, Luka Čičin ; Jonjić, Stipan ; Lisnić, Vanda Juranić ; Brizić, Ilija

Izvornik
Viruses (1999-4915) 14 (2022), 9; 2-22

Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni

Ključne riječi
SARS-CoV-2 ; COVID-19 ; healthcare workers ; COVID-19 vaccine ; BNT162 vaccine ; hospitalized patients ; antibody detection ; Spike ; Nucleocapsid ; Omicron

Sažetak
Studies assessing the dynamics and duration of antibody responses following SARS-CoV-2 infection or vaccination are an invaluable tool for vaccination schedule planning, assessment of risk groups and management of pandemics. In this study, we developed and employed ELISA assays to analyze the humoral responses to Nucleocapsid and Spike proteins in vaccinated health-care workers (HCW) and critically ill COVID-19 patients. Sera of more than 1000 HCWs and critically ill patients from the Clinical Hospital Center Rijeka were tested across a one-year period, encompassing the spread of major SARS-CoV-2 variants of concern (VOCs). We observed 97% of seroconversion in HCW cohort as well as sustained anti-Spike antibody response in vaccinees for more than 6 months. In contrast, the infection-induced anti-Nucleocapsid response was waning significantly in a six-month period. Furthermore, a substantial decrease in vaccinees’ anti-Spike antibodies binding to Spike protein of Omicron VOC was also observed. Critically ill COVID-19 patients had higher levels of anti-Spike and anti-Nucleocapsid antibodies compared to HCWs. No significant differences in anti-Spike and anti- Nucleocapsid antibody levels between the critically ill COVID-19 patients that were on non- invasive oxygen supplementation and those on invasive ventilation support were observed. However, stronger anti-Spike, but not anti- Nucleocapsid, antibody response correlated with a better disease outcome in the cohort of patients on invasive ventilation support. Altogether, our results contribute to the growing pool of data on humoral responses to SARS-CoV-2 infection and vaccination.

Izvorni jezik
Engleski

Znanstvena područja
Temeljne medicinske znanosti



POVEZANOST RADA


Projekti:
--IP-CORONA-2020-04-2073 - Dosta skrivanja CoV-2: uspostava baze monoklonskih protutijela na SARS-Cov-2 (CoV2mAbs) (Brizić, Ilija) ( CroRIS)

Ustanove:
Medicinski fakultet, Rijeka

Poveznice na cjeloviti tekst rada:

doi www.mdpi.com

Citiraj ovu publikaciju:

Brlić, Paola Kučan; Pavletić, Martina; Lerga, Mate; Krstanović, Fran; Matešić, Marina Pribanić; Miklić, Karmela; Malić, Suzana; Mikša, Leonarda; Pajcur, Maja; Peruč, Dolores et al.
SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study // Viruses, 14 (2022), 9; 2-22 doi:10.3390/v14091966 (međunarodna recenzija, članak, znanstveni)
Brlić, P., Pavletić, M., Lerga, M., Krstanović, F., Matešić, M., Miklić, K., Malić, S., Mikša, L., Pajcur, M. & Peruč, D. (2022) SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study. Viruses, 14 (9), 2-22 doi:10.3390/v14091966.
@article{article, author = {Brli\'{c}, Paola Ku\v{c}an and Pavleti\'{c}, Martina and Lerga, Mate and Krstanovi\'{c}, Fran and Mate\v{s}i\'{c}, Marina Pribani\'{c} and Mikli\'{c}, Karmela and Mali\'{c}, Suzana and Mik\v{s}a, Leonarda and Pajcur, Maja and Peru\v{c}, Dolores and Schubert, Maren and Bertoglio, Federico and Arapovi\'{c}, Jurica and Proti\'{c}, Alen and \v{S}usti\'{c}, Alan and Milo\v{s}evi\'{c}, Marko and \v{S}ain, Luka \v{C}i\v{c}in and Jonji\'{c}, Stipan and Lisni\'{c}, Vanda Jurani\'{c} and Brizi\'{c}, Ilija}, year = {2022}, pages = {2-22}, DOI = {10.3390/v14091966}, keywords = {SARS-CoV-2, COVID-19, healthcare workers, COVID-19 vaccine, BNT162 vaccine, hospitalized patients, antibody detection, Spike, Nucleocapsid, Omicron}, journal = {Viruses}, doi = {10.3390/v14091966}, volume = {14}, number = {9}, issn = {1999-4915}, title = {SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study}, keyword = {SARS-CoV-2, COVID-19, healthcare workers, COVID-19 vaccine, BNT162 vaccine, hospitalized patients, antibody detection, Spike, Nucleocapsid, Omicron} }
@article{article, author = {Brli\'{c}, Paola Ku\v{c}an and Pavleti\'{c}, Martina and Lerga, Mate and Krstanovi\'{c}, Fran and Mate\v{s}i\'{c}, Marina Pribani\'{c} and Mikli\'{c}, Karmela and Mali\'{c}, Suzana and Mik\v{s}a, Leonarda and Pajcur, Maja and Peru\v{c}, Dolores and Schubert, Maren and Bertoglio, Federico and Arapovi\'{c}, Jurica and Proti\'{c}, Alen and \v{S}usti\'{c}, Alan and Milo\v{s}evi\'{c}, Marko and \v{S}ain, Luka \v{C}i\v{c}in and Jonji\'{c}, Stipan and Lisni\'{c}, Vanda Jurani\'{c} and Brizi\'{c}, Ilija}, year = {2022}, pages = {2-22}, DOI = {10.3390/v14091966}, keywords = {SARS-CoV-2, COVID-19, healthcare workers, COVID-19 vaccine, BNT162 vaccine, hospitalized patients, antibody detection, Spike, Nucleocapsid, Omicron}, journal = {Viruses}, doi = {10.3390/v14091966}, volume = {14}, number = {9}, issn = {1999-4915}, title = {SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study}, keyword = {SARS-CoV-2, COVID-19, healthcare workers, COVID-19 vaccine, BNT162 vaccine, hospitalized patients, antibody detection, Spike, Nucleocapsid, Omicron} }

Časopis indeksira:


  • Web of Science Core Collection (WoSCC)
    • Science Citation Index Expanded (SCI-EXP)
    • SCI-EXP, SSCI i/ili A&HCI
  • Scopus
  • MEDLINE


Citati:





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