Pregled bibliografske jedinice broj: 1223291
SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study
SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study // Viruses, 14 (2022), 9; 2-22 doi:10.3390/v14091966 (međunarodna recenzija, članak, znanstveni)
CROSBI ID: 1223291 Za ispravke kontaktirajte CROSBI podršku putem web obrasca
Naslov
SARS-CoV-2 Spike and Nucleocapsid Antibody
Response in Vaccinated Croatian Healthcare Workers
and Infected Hospitalized Patients: A Single
Center Cohort Study
Autori
Brlić, Paola Kučan ; Pavletić, Martina ; Lerga, Mate ; Krstanović, Fran ; Matešić, Marina Pribanić ; Miklić, Karmela ; Malić, Suzana ; Mikša, Leonarda ; Pajcur, Maja ; Peruč, Dolores ; Schubert, Maren ; Bertoglio, Federico ; Arapović, Jurica ; Protić, Alen ; Šustić, Alan ; Milošević, Marko ; Šain, Luka Čičin ; Jonjić, Stipan ; Lisnić, Vanda Juranić ; Brizić, Ilija
Izvornik
Viruses (1999-4915) 14
(2022), 9;
2-22
Vrsta, podvrsta i kategorija rada
Radovi u časopisima, članak, znanstveni
Ključne riječi
SARS-CoV-2 ; COVID-19 ; healthcare workers ; COVID-19 vaccine ; BNT162 vaccine ; hospitalized patients ; antibody detection ; Spike ; Nucleocapsid ; Omicron
Sažetak
Studies assessing the dynamics and duration of antibody responses following SARS-CoV-2 infection or vaccination are an invaluable tool for vaccination schedule planning, assessment of risk groups and management of pandemics. In this study, we developed and employed ELISA assays to analyze the humoral responses to Nucleocapsid and Spike proteins in vaccinated health-care workers (HCW) and critically ill COVID-19 patients. Sera of more than 1000 HCWs and critically ill patients from the Clinical Hospital Center Rijeka were tested across a one-year period, encompassing the spread of major SARS-CoV-2 variants of concern (VOCs). We observed 97% of seroconversion in HCW cohort as well as sustained anti-Spike antibody response in vaccinees for more than 6 months. In contrast, the infection-induced anti-Nucleocapsid response was waning significantly in a six-month period. Furthermore, a substantial decrease in vaccinees’ anti-Spike antibodies binding to Spike protein of Omicron VOC was also observed. Critically ill COVID-19 patients had higher levels of anti-Spike and anti-Nucleocapsid antibodies compared to HCWs. No significant differences in anti-Spike and anti- Nucleocapsid antibody levels between the critically ill COVID-19 patients that were on non- invasive oxygen supplementation and those on invasive ventilation support were observed. However, stronger anti-Spike, but not anti- Nucleocapsid, antibody response correlated with a better disease outcome in the cohort of patients on invasive ventilation support. Altogether, our results contribute to the growing pool of data on humoral responses to SARS-CoV-2 infection and vaccination.
Izvorni jezik
Engleski
Znanstvena područja
Temeljne medicinske znanosti
POVEZANOST RADA
Projekti:
--IP-CORONA-2020-04-2073 - Dosta skrivanja CoV-2: uspostava baze monoklonskih protutijela na SARS-Cov-2 (CoV2mAbs) (Brizić, Ilija) ( CroRIS)
Ustanove:
Medicinski fakultet, Rijeka
Profili:
Dolores Peruč
(autor)
Ilija Brizić
(autor)
Alan Šustić
(autor)
Jurica Arapović
(autor)
Fran Krstanović
(autor)
Stipan Jonjić
(autor)
Martina Pavletić
(autor)
Paola Kučan Brlić
(autor)
Alen Protić
(autor)
Citiraj ovu publikaciju:
Časopis indeksira:
- Web of Science Core Collection (WoSCC)
- Science Citation Index Expanded (SCI-EXP)
- SCI-EXP, SSCI i/ili A&HCI
- Scopus
- MEDLINE