Naslov
QSAR OF ANTIPROLIFERATIVE EFFECTS OF HALOGEN-, AND AMIDINO-SUBSTITUTED BENZOTHIAZOLES AND BENZIMIDAZOLES

Autori
Rastija, Vesna ; Šubarić, Domagoj ; Karnaš, Maja ; Glavaš-Obrovac, Ljubica ; Raić-Malić, Silvana

Vrsta, podvrsta i kategorija rada
Sažeci sa skupova, sažetak, znanstveni

Izvornik
23rd European Symposium on Quantitative Structure-Activity Relationship, Integrative Data-Intensive Approaches to Drug Design, Book of Abstracts / - Heidelberg, 2022, P038-P038

Skup
23rd European Symposium on Quantitative Structure- Activity Relationship, Integrative Data-Intensive Approaches to Drug Design

Mjesto i datum
Heidelberg, Njemačka, 26.09.2022. - 30.09.2022

Vrsta sudjelovanja
Poster

Vrsta recenzije
Međunarodna recenzija

Ključne riječi
QSAR, benzothiazoles, benzimidazoles, cytotoxic effect, lymphoma

Sažetak
Novel derivates of benzothiazoles and benzimidazoles have been evaluated on T-cell lymphoma (HuT78), as well as on normal Madin-Darby canine kidney cells (MDCK-1). Cytotoxic effects of 77 benzothiazoles and benzimidazoles against non-tumour MDCK-1 cells were ranked by activities, and 17 compounds were chosen for the test set. The best QSAR model expressed by multiple linear regression equation was generated by five molecular descriptors calculated by DRAGON program: SIC1, GATS4p, BEHv6, BELp1, and R7m. Williams plot of the applicability domain, detected one molecule as a border outlier and no molecule out of the warning leverage. After removing outlier, the new model has the model achieved better statistical performance of internal and external validation: R2train = 0.74 ; F = 30.76 ; ΔK = 0.08 ; CCCtr = 0.85 ; Q2loo = 0.68 ; CCCcv = 0.81 ; R2Yscr = 0.09 ; Q2Yscr = -0.13 ; R2ext = 0.83 ; CCCext = 0.85 ; Δr2m = 0.25. Molecules without atoms with higher atomic mass as substituents (Cl, F) and more equal neighbor atoms have higher activity. QSAR study for antiproliferative activity on T-cell lymphoma (HuT78) cell was performed on a total of 59 molecules (47 training, 12 test set). The best-obtained model includes three descriptors: MATS8v, Mor09p, Mor30m, and E2u. After exclusion of three outliers from data set, relived by Williams plot (Figure 1) resulted on the predictive model: R2train = 0.87 ; F = 66.48 ; ΔK = 0.12 ; CCCtr = 0.93 ; Q2loo = 0.83 ; CCCcv = 0.91 ; R2Yscr = 0.09 ; Q2Yscr = -0.15 ; R2ext = 0.87 ; CCCext = 0.85 ; Δr2m = 0.13. An increasing number of atomic van der Waals volumes, such as in sulphur atom in benzothiazoles, as molecules without atoms, have higher atomic mass as substituents (Cl, F) enhancing antiproliferative activity on MDCK-1 cells.

Izvorni jezik
Engleski

Znanstvena područja
Kemija, Farmacija

POVEZANOST RADA